PDF(Pubmed)
Abstract：
Magnetoreceptive biology as a field remains relatively obscure; compared with the breadth of species believed to sense magnetic fields, it remains under-studied. Here, we present grounds for the expansion of magnetoreception studies among teleosts. We begin with the electromagnetic perceptive gene (EPG) from Kryptopterus vitreolus and expand to identify 72 teleosts with homologous proteins containing a conserved three-phenylalanine (3F) motif. Phylogenetic analysis provides insight as to how EPG may have evolved over time and indicates that certain clades may have experienced a loss of function driven by different fitness pressures. One potential factor is water type with freshwater fish significantly more likely to possess the functional motif version (FFF), and saltwater fish to have the non-functional variant (FXF). It was also revealed that when the 3F motif from the homologue of Brachyhypopomus gauderio (B.g.) is inserted into EPG-EPG(B.g.)-the response (as indicated by increased intracellular calcium) is faster. This indicates that EPG has the potential to be engineered to improve upon its response and increase its utility to be used as a controller for specific outcomes.
摘要：
磁感受生物学作为一个领域仍然相对模糊；与被认为能感知磁场的物种的广度相比，它仍然被研究不足。这里,我们提出了在硬骨鱼中扩展磁接收研究的理由。我们从玻璃体Kryptopterus的电磁感知基因（EPG）开始，并扩展到鉴定72个硬骨鱼，其同源蛋白包含保守的三苯丙氨酸（3F）基序。系统发育分析提供了有关EPG如何随时间演变的见解，并表明某些进化枝可能经历了由不同健身压力驱动的功能丧失。一个潜在的因素是淡水鱼的水型更有可能具有功能基序版本（FFF），和咸水鱼具有非功能性变体（FXF）。还揭示了，当将来自长尾囊瘤（B.g.）同源物的3F基序插入EPG-EPG（B.g.）时，反应（如细胞内钙增加所示）更快。这表明EPG有可能被设计为改善其响应并增加其用作特定结果的控制器的效用。
