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Abstract：
Matrine (MT) and Oxymatrine (OMT) are two natural alkaloids derived from plants. These bioactive compounds are notable for their diverse pharmacological effects and have been extensively studied and recognized in the treatment of cardiovascular diseases in recent years. The cardioprotective effects of MT and OMT involve multiple aspects, primarily including antioxidative stress, anti-inflammatory actions, anti-atherosclerosis, restoration of vascular function, and inhibition of cardiac remodeling and failure. Clinical pharmacology research has identified numerous novel molecular mechanisms of OMT and MT, such as JAK/STAT, Nrf2/HO-1, PI3 K/AKT, TGF-β1/Smad, and Notch pathways, providing new evidence supporting their promising therapeutic potential against cardiovascular diseases. Thus, this review aims to investigate the potential applications of MT and OMT in treating cardiovascular diseases, encompassing their mechanisms, efficacy, and safety, confirming their promise as lead compounds in anti-cardiovascular disease drug development.
摘要：
苦参碱(MT)和氧化苦参碱(OMT)是来源于植物的两种天然生物碱。这些生物活性化合物以其不同的药理作用而著称,并且近年来在心血管疾病的治疗中得到了广泛的研究和认可。MT和OMT的心脏保护作用涉及多个方面,主要包括抗氧化应激，抗炎作用，抗动脉粥样硬化，血管功能的恢复，抑制心脏重塑和衰竭。临床药理学研究已经确定了许多新的OMT和MT的分子机制，如JAK/STAT，Nrf2/HO-1,PI3K/AKT,TGF-β1/Smad,和缺口路径，提供新的证据支持他们有希望的治疗心血管疾病的潜力。因此，本文旨在探讨MT和OMT在心血管疾病治疗中的潜在应用,包括他们的机制，功效,和安全,证实了他们在抗心血管疾病药物开发中作为先导化合物的前景。
