PDF(Pubmed)
Abstract：
UNASSIGNED: Mycoplasma pneumoniae (Mp) is one of the major pathogens that causes respiratory tract infections, and macrolide resistance has increased rapidly in recent years due to the inappropriate use of macrolides in northeastern Asia. In the present study, we aimed to investigate Mp infection and macrolide resistance during a period of high incidence of Mp infection in Henan, China.
UNASSIGNED: A total of 29473 suspected children with Mp infection were enrolled in the study from July to December 2023. Throat swab specimens were collected from all the study subjects, and real-time PCR was performed to detect the Mp-DNA and macrolide resistance-associated A2063G or A2064G mutations.
UNASSIGNED: The overall percentage of Mp-DNA-positive patients was 51.1 %, and the percentage of macrolide-resistant strains was 91 %. The rate of macrolide resistance remained stable from July to December. The Mp-DNA positivity rates among the different age groups from low to high were 0-1, 1-3, 3-6, 10-18 and 6-10 years. The macrolide resistance rate was the lowest in the 0-1 age group and highest in the 6-10 age group. No difference in the rate of macrolide resistance was observed between male and female children.
UNASSIGNED: The macrolide resistance rate of Mp did not change during the investigated period of high incidence of infection, and no sex difference existed. The macrolide resistance rate of Mp was the lowest in children under 1 year old.
UNASSIGNED: A total of 29473 suspected children with Mp infection were enrolled in the study from July to December 2023. Throat swab specimens were collected from all the study subjects, and real-time PCR was performed to detect the Mp-DNA and macrolide resistance-associated A2063G or A2064G mutations.
UNASSIGNED: The overall percentage of Mp-DNA-positive patients was 51.1 %, and the percentage of macrolide-resistant strains was 91 %. The rate of macrolide resistance remained stable from July to December. The Mp-DNA positivity rates among the different age groups from low to high were 0-1, 1-3, 3-6, 10-18 and 6-10 years. The macrolide resistance rate was the lowest in the 0-1 age group and highest in the 6-10 age group. No difference in the rate of macrolide resistance was observed between male and female children.
UNASSIGNED: The macrolide resistance rate of Mp did not change during the investigated period of high incidence of infection, and no sex difference existed. The macrolide resistance rate of Mp was the lowest in children under 1 year old.
摘要：
■肺炎支原体（Mp）是引起呼吸道感染的主要病原体之一，近年来，由于东北亚大环内酯类药物的不当使用，大环内酯类药物的耐药性迅速增加。在本研究中,我们旨在调查河南省Mp感染高发时期的Mp感染和大环内酯耐药性，中国。
■从2023年7月至12月，共有29473名疑似感染Mp的儿童被纳入研究。从所有研究对象中收集咽拭子标本，并进行实时PCR以检测Mp-DNA和大环内酯抗性相关的A2063G或A2064G突变。
■Mp-DNA阳性患者的总体百分比为51.1%，大环内酯耐药菌株的比例为91%。7月至12月大环内酯耐药率保持稳定。不同年龄组Mp-DNA阳性率从低到高依次为0-1、1-3、3-6、10-18和6-10岁。大环内酯耐药率在0-1岁年龄组最低，在6-10岁年龄组最高。男性和女性儿童对大环内酯的耐药率没有差异。
■在高感染率的调查期间，Mp的大环内酯耐药率没有变化，不存在性别差异.1岁以下儿童Mp的大环内酯耐药率最低。
■从2023年7月至12月，共有29473名疑似感染Mp的儿童被纳入研究。从所有研究对象中收集咽拭子标本，并进行实时PCR以检测Mp-DNA和大环内酯抗性相关的A2063G或A2064G突变。
■Mp-DNA阳性患者的总体百分比为51.1%，大环内酯耐药菌株的比例为91%。7月至12月大环内酯耐药率保持稳定。不同年龄组Mp-DNA阳性率从低到高依次为0-1、1-3、3-6、10-18和6-10岁。大环内酯耐药率在0-1岁年龄组最低，在6-10岁年龄组最高。男性和女性儿童对大环内酯的耐药率没有差异。
■在高感染率的调查期间，Mp的大环内酯耐药率没有变化，不存在性别差异.1岁以下儿童Mp的大环内酯耐药率最低。
