PDF(Pubmed)
Abstract：
Aim: Atypical teratoid rhabdoid tumor (ATRT) is a rare and highly aggressive primary CNS neoplasm, predominantly observed in children. The use of autologous stem cell transplantation (ASCT) in pediatric ATRT has shown promise; however, its utility in adult ATRT remains unclear. Patients & methods: This study presents the case of an adult patient with ATRT who is in remission after ASCT and reviews the literature on ASCT in adults with ATRT. Four cases of ATRT in adults who underwent ASCT were identified, with pertinent data summarized. Results: All five patients survived longer than the historical average survival rate, four of whom had no clinical or radiographic evidence of disease at the final follow-up. Conclusion: Based on limited data, there may be a role for ASCT in the treatment of adults with ATRT.
[Box: see text].
[Box: see text].
摘要：
目的：非典型畸胎瘤样横纹肌样瘤（ATRT）是一种罕见且高度侵袭性的原发性中枢神经系统肿瘤，主要在儿童中观察到。在儿科ATRT中使用自体干细胞移植（ASCT）已显示出希望；然而，其在成人ATRT中的效用尚不清楚。患者和方法：本研究介绍了ATRT成年患者在ASCT后缓解的情况，并回顾了ATRT成人中ASCT的文献。确定了4例接受ASCT的成人ATRT，总结了相关数据。结果：所有5例患者的生存时间均超过历史平均生存率，其中4人在最后一次随访时没有疾病的临床或影像学证据.结论：基于有限的数据，ASCT可能在成人ATRT治疗中发挥作用.
[方框：见正文]。
[方框：见正文]。
