Abstract：
Rift Valley fever virus (RVFV) is an arboviral pathogen of clinical and agricultural relevance. The ongoing development of targeted RVFV prophylactics and therapeutics is overwhelmingly dependent on animal models due to both natural, that is, sporadic outbreaks, and structural, for example, underresourcing of endemic regions, limitations in accessing human patient samples and cohorts. Elucidating mechanisms of viral pathogenesis and testing therapeutics is further complicated by the diverse manifestations of RVFV disease and the heterogeneity of the host response to infection. In this chapter, we describe major clinical manifestations of RVFV infection and discuss the laboratory animal models used to study each.
摘要：
裂谷热病毒（RVFV）是临床和农业相关的虫媒病毒病原体。靶向RVFV预防和治疗的正在进行的开发在很大程度上依赖于动物模型，也就是说,零星爆发，和结构，例如,地方病资源不足，在获取人类患者样本和队列方面的限制。病毒发病机理的阐明机制和测试疗法由于RVFV疾病的多种表现和宿主对感染的反应的异质性而进一步复杂化。在这一章中,我们描述了RVFV感染的主要临床表现，并讨论了用于研究的实验动物模型。
