Abstract：
The Rift Valley fever virus (RVFV) is an arthropod-borne, zoonotic, hemorrhagic fever virus that can cause severe diseases both in livestock and humans. The spread of RVFV in areas previously considered as non-endemic together with the absence of licensed vaccines for use in humans and animals poses a major health and economic threat worldwide. It is therefore crucial to make major progresses in our understanding and management of this virus and its zoonosis. RVFV is considered a bioterrorism pathogen, and, thus, only a few institutes, facilities, and personnel are legally authorized to detain it and handle it. Moreover, this virus must be manipulated in a biosafety level 3 (BSL3) laboratory following strict biosafety protocols to ensure that biosecurity\'s highest standards are met. Only certain attenuated strains such as the MP12 strain can be handled in BSL2 laboratories, depending on the country considered. To assist researchers in working with RVFV in the safest possible conditions, this chapter presents validated methods for effective RVFV decontamination and inactivation.
摘要：
裂谷热病毒（RVFV）是节肢动物传播的，人畜共患,出血热病毒，可在牲畜和人类中引起严重疾病。RVFV在以前被认为是非地方病的地区的传播，以及缺乏用于人类和动物的许可疫苗，在全球范围内构成了重大的健康和经济威胁。因此，在我们对这种病毒及其人畜共患病的理解和管理方面取得重大进展至关重要。RVFV被认为是生物恐怖主义病原体，and,因此，只有少数机构，设施,法律授权人员拘留和处理。此外，这种病毒必须在生物安全3级（BSL3）实验室按照严格的生物安全协议进行操作，以确保达到生物安全的最高标准。BSL2实验室只能处理某些减毒株，如MP12株，取决于所考虑的国家。为了帮助研究人员在最安全的条件下使用RVFV，本章介绍了有效的RVFV净化和灭活的有效方法。
