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Abstract：
Ataxin-2 (ATXN2) was originally discovered in the context of spinocerebellar ataxia type 2 (SCA2), but it has become a key player in various neurodegenerative diseases. This review delves into the multifaceted roles of ATXN2 in human diseases, revealing its diverse molecular and cellular pathways. The impact of ATXN2 on diseases extends beyond functional outcomes; it mainly interacts with various RNA-binding proteins (RBPs) to regulate different stages of post-transcriptional gene expression in diseases. With the progress of research, ATXN2 has also been found to play an important role in the development of various cancers, including breast cancer, gastric cancer, pancreatic cancer, colon cancer, and esophageal cancer. This comprehensive exploration underscores the crucial role of ATXN2 in the pathogenesis of diseases and warrants further investigation by the scientific community. By reviewing the latest discoveries on the regulatory functions of ATXN2 in diseases, this article helps us understand the complex molecular mechanisms of a series of human diseases related to this intriguing protein.
摘要：
Ataxin-2（ATXN2）最初是在脊髓小脑共济失调2型（SCA2）的背景下发现的，但它已经成为各种神经退行性疾病的关键角色。这篇综述探讨了ATXN2在人类疾病中的多方面作用。揭示其不同的分子和细胞途径。ATXN2对疾病的影响超出了功能结果；它主要与各种RNA结合蛋白（RBP）相互作用，以调节疾病中转录后基因表达的不同阶段。随着研究的进展,还发现ATXN2在各种癌症的发展中起重要作用，包括乳腺癌,胃癌,胰腺癌,结肠癌,还有食道癌.这种全面的探索强调了ATXN2在疾病发病机理中的关键作用，值得科学界进一步研究。通过回顾ATXN2在疾病中的调节功能的最新发现，这篇文章帮助我们了解与这种有趣的蛋白质有关的一系列人类疾病的复杂分子机制。
