Abstract：
Peripheral nerve injury (PNI) poses a significant public health issue, often leading to muscle atrophy and persistent neuropathic pain, which can drastically impact the quality of life for patients. Electrical stimulation represents an effective and non-pharmacological treatment to promote nerve regeneration. Yet, the postoperative application of electrical stimulation remains a challenge. Here, we propose a fully biodegradable, self-powered nerve guidance conduit (NGC) based on dissolvable zinc-molybdenum batteries. The conduit can offer topographic guidance for nerve regeneration and deliver sustained electrical cues between both ends of a transected nerve stump, extending beyond the surgical window. Schwann cell proliferation and adenosine triphosphate (ATP) production are enhanced by the introduction of the zinc-molybdenum batteries. In rodent models with 10-mm sciatic nerve damage, the device effectively enhances nerve regeneration and motor function recovery. This study offers innovative strategies for creating biodegradable and electroactive devices that hold important promise to optimize therapeutic outcomes for nerve regeneration.
摘要：
周围神经损伤（PNI）是一个重大的公共卫生问题，通常导致肌肉萎缩和持续性神经性疼痛，这会严重影响患者的生活质量。电刺激代表促进神经再生的有效和非药物治疗。然而，电刺激的术后应用仍然是一个挑战.这里,我们提出了一种完全可生物降解的，基于可溶性锌钼电池的自供电神经引导导管（NGC）。导管可以为神经再生提供地形指导，并在横切的神经残端的两端之间提供持续的电提示，延伸到手术窗口之外。通过引入锌-钼电池，可以增强施万细胞的增殖和三磷酸腺苷（ATP）的产生。在10毫米坐骨神经损伤的啮齿动物模型中，该装置有效促进神经再生和运动功能恢复。这项研究为创建可生物降解和电活性设备提供了创新策略，这些设备具有重要的希望，可以优化神经再生的治疗效果。
