PDF(Pubmed)
Abstract：
Ginsenosides in ginseng are known for their potential health benefits, including antioxidant properties and their potential to exhibit anticancer effects. Besides a various range of coding genes, ginsenosides impose their efficacy by targeting noncoding RNAs. Long noncoding RNA ( lncRNA) has gained significant attention from both basic and clinical oncology fields due to its involvement in various cancer cell activities such as proliferation, apoptosis, metastasis, and autophagy. These events can be achieved either by lncRNA alone or in association with microRNAs or proteins. This review aims to summarize the diverse activities of lncRNAs that are regulated by ginsenosides, focusing on their role in regulating target genes through signaling pathways in human diseases. We highlight the results of studies on the expression profiles of lncRNAs induced by ginsenosides in efforts to inhibit cancer cell proliferation. Finally, we discuss the potential and challenges of utilizing lncRNAs as diagnostic markers for disease treatment.
摘要：
人参中的人参皂苷以其潜在的健康益处而闻名，包括抗氧化特性和它们表现出抗癌作用的潜力。除了各种编码基因，人参皂苷通过靶向非编码RNA来发挥其功效。长链非编码RNA（lncRNA）由于其参与各种癌细胞活动（如增殖）而受到基础和临床肿瘤学领域的广泛关注，凋亡，转移,和自噬。这些事件可以通过单独的lncRNA或与microRNA或蛋白质结合来实现。这篇综述旨在总结人参皂苷调控的lncRNAs的不同活性,关注它们在人类疾病中通过信号通路调节靶基因的作用。我们强调了人参皂苷在抑制癌细胞增殖中诱导的lncRNAs表达谱的研究结果。最后,我们讨论了利用lncRNAs作为疾病治疗的诊断标记的潜力和挑战。
