PDF(Pubmed)
Abstract：
Pernicious anemia, stemming from Vitamin B12 deficiency and autoimmune processes affecting intrinsic factor production, presents challenges in early diagnosis due to vague initial symptoms. This case report introduces a unique occurrence of pernicious anemia-induced peripheral neuropathy in a patient with concurrent HLA-B27 arthropathy, highlighting the complex interplay of autoimmune mechanisms. While HLA-B27 is not typically associated with pernicious anemia, the case underscores the importance of exploring specific HLA haplotypes in understanding the nuanced manifestation of autoimmune disorders. Comprehensive screening for anti-intrinsic factor and anti-parietal cell antibodies is crucial in individuals with signs of pernicious anemia, especially those with a history of HLA-B27 arthropathy, guiding tailored management strategies. This report contributes to the ongoing exploration of the intricate autoimmune landscape in pernicious anemia.
摘要：
恶性贫血,源于维生素B12缺乏和影响内在因子产生的自身免疫过程，由于模糊的初始症状，在早期诊断中提出了挑战。该病例报告介绍了并发HLA-B27关节病的患者中恶性贫血诱发的周围神经病变的独特发生。强调自身免疫机制的复杂相互作用。虽然HLA-B27通常与恶性贫血无关，该病例强调了探索特定HLA单倍型对于了解自身免疫性疾病的细微差别表现的重要性.在有恶性贫血迹象的个体中，全面筛查抗内在因子和抗壁细胞抗体至关重要，尤其是那些有HLA-B27关节病病史的人，指导量身定制的管理策略。本报告有助于不断探索恶性贫血中复杂的自身免疫景观。
