{Reference Type}: Case Reports
{Title}: An Uncommon Association: HLA-B27 Positivity in Conjunction With Pernicious Anemia - A Case Report and Literature Review.
{Author}: Auda AH;Atoot R;Jurri M;Mahmoud A;Siddiqui A;Bangolo A;Malik T;Baker I;Sotiriadis J;
{Journal}: J Community Hosp Intern Med Perspect
{Volume}: 14
{Issue}: 3
{Year}: 2024
暂无{DOI}: 10.55729/2000-9666.1340
{Abstract}: Pernicious anemia, stemming from Vitamin B12 deficiency and autoimmune processes affecting intrinsic factor production, presents challenges in early diagnosis due to vague initial symptoms. This case report introduces a unique occurrence of pernicious anemia-induced peripheral neuropathy in a patient with concurrent HLA-B27 arthropathy, highlighting the complex interplay of autoimmune mechanisms. While HLA-B27 is not typically associated with pernicious anemia, the case underscores the importance of exploring specific HLA haplotypes in understanding the nuanced manifestation of autoimmune disorders. Comprehensive screening for anti-intrinsic factor and anti-parietal cell antibodies is crucial in individuals with signs of pernicious anemia, especially those with a history of HLA-B27 arthropathy, guiding tailored management strategies. This report contributes to the ongoing exploration of the intricate autoimmune landscape in pernicious anemia.