PDF(Pubmed)
Abstract：
This case report presents a 59-year-old female patient with mandibular gingival metastasis from adenocarcinoma of the sigmoid part of the colon, who underwent radical colectomy with simultaneous hysterectomy involving and left oophorectomy (due to tumor involvement) eight years ago. Because of metastatic spread to the liver, a partial left lateral lobectomy was performed, and because of a metastatic lesion in the left adrenal gland, the latter was excised and a partial resection of the left kidney was performed. The patient was given a number of courses of chemotherapy, target therapy, and immunotherapy. In 2024, because of a tumor mass in the oral cavity that was growing and interfering with normal nutrition and speech, she was hospitalized and a radical resection of the lesion was performed along with the involved underlying bone of the lower jaw on the right. The morphological analysis revealed metastasis from large cell neuroendocrine carcinoma and the immunohistochemical stains verified the gastrointestinal origin of the lesion. The lesion was accepted as being a result of the phenotypical transformation of the primary adenocarcinoma of the sigmoid colon. The patient had a normal postoperative period and a smoothly healing wound and continued to be under the management of clinical oncologists supporting chemo-, targeted, and immunotherapy. However, five months after the appearance of the lesion and three months after its surgical removal, after a serious deterioration of her general condition, she passed away at home.
摘要：
该病例报告介绍了一名59岁的女性患者，患有结肠乙状结肠部分腺癌的下颌牙龈转移，8年前接受了根治性结肠切除术，同时进行子宫切除术和左卵巢切除术（由于肿瘤受累）。因为转移扩散到肝脏，进行了部分左侧叶切除术，因为左肾上腺的转移性病变,切除后者,并对左肾进行部分切除.病人接受了几个疗程的化疗,靶向治疗,和免疫疗法。2024年，由于口腔中的肿瘤块正在生长并干扰正常的营养和言语，她住院，并对病变进行了根治性切除，同时切除了右侧下颌受累的下颌骨。形态学分析显示大细胞神经内分泌癌转移，免疫组织化学染色证实了病变的胃肠道起源。该病变被认为是乙状结肠原发性腺癌表型转化的结果。患者术后时间正常，伤口愈合顺利，并继续接受临床肿瘤学家的治疗，有针对性的,和免疫疗法。然而,病变出现后五个月和手术切除后三个月，在她的一般状况严重恶化之后，她在家里去世了。
