关键词: Ischemic stroke intravenous thrombolysis tenecteplase thrombolysis alert

Mesh : Humans Morocco Female Middle Aged Ischemic Stroke / drug therapy Male Thrombolytic Therapy / methods adverse effects Prospective Studies Aged Fibrinolytic Agents / administration & dosage adverse effects Cross-Sectional Studies Adult Time-to-Treatment Tenecteplase / administration & dosage adverse effects Emergency Service, Hospital / statistics & numerical data Time Factors Thrombectomy / methods Follow-Up Studies Tissue Plasminogen Activator / administration & dosage adverse effects Aged, 80 and over

来  源:   DOI:10.11604/pamj.2024.47.167.42376   PDF(Pubmed)

Abstract:
Intravenous thrombolysis is the standard treatment for acute ischemic stroke. We here report the cases of thrombolysis alert in the private sector in Morocco We conducted a prospective study of all patients with neurological deficit of sudden onset occurred within the first 12 hours admitted to the Emergency Department of the Al Badie international private clinic from January 2022 to September 2023. Epidemiological, clinical and etiological characteristics as well as data on outpatient and inpatient delays were collected. Sixty patients were included in the study. The average admission delay was 198.36 ± 79.23 minutes. The mean NIHSS (National Institutes of Health Stroke Scale) score was 10.41 ± 4.97. The average time for imaging was 26.68 ± 9.63 minutes. Ischaemic stroke was the most common diagnosis (85%), followed by \"stroke mimics\" (11.6%). Thirteen patients underwent thrombolysis with tenecteplase. The mean time from admission to the initiation of thrombolysis was 107.15 ± 24.48 minutes. Follow-up imaging at 24 hours post thrombolysis revealed symptomatic haemorrhagic transformation in 3 patients. Six patients were transferred to the Hassan II University Hospital for thrombolysis and/or mechanical thrombectomy. After 3 months, 4 patients were autonomous (Rankin score changed between 0 and 2). Our experience shows that it is imperative to reduce outpatient and inpatient delays in treatment in order to increase the proportion of patients treated with thrombolysis.
摘要:
静脉溶栓是急性缺血性卒中的标准治疗方法。我们在此报告摩洛哥私营部门的溶栓警报病例我们对2022年1月至2023年9月AlBadie国际私人诊所急诊科收治的所有突发性神经功能缺损患者进行了前瞻性研究。流行病学,收集了临床和病因学特征以及门诊和住院延误的数据.该研究包括60名患者。平均入院延迟为198.36±79.23分钟。NIHSS(美国国立卫生研究院卒中量表)平均得分为10.41±4.97。平均成像时间为26.68±9.63分钟。缺血性卒中是最常见的诊断(85%),其次是“中风模仿”(11.6%)。13例患者接受替奈普酶溶栓治疗。从入院到开始溶栓的平均时间为107.15±24.48分钟。溶栓后24小时的随访影像学显示3例患者有症状性出血转化。六名患者被转移到哈桑二世大学医院进行溶栓和/或机械血栓切除术。三个月后,4例患者自主(Rankin评分在0和2之间变化)。我们的经验表明,必须减少门诊和住院患者的治疗延误,以增加接受溶栓治疗的患者比例。
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