PDF(Pubmed)
Abstract：
UNASSIGNED: The long-lasting persistence of autoantibodies stands as one of the hypotheses explaining the multisystemic manifestations seen in individuals with post-COVID-19 condition. The current review offers restricted insights into the persistence of autoantibodies in plasma/serum in people with post-COVID symptoms.
UNASSIGNED: PubMed/MEDLINE, CINAHL, EMBASE, and Web of Science databases, as well as on medRxiv and bioRxiv preprint servers were searched up to January 5th, 2024. Papers investigating the presence of autoantibodies in plasma/serum samples in people with post-COVID symptoms were included. The Newcastle-Ottawa Scale (NOS) was used to assess methodological quality.
UNASSIGNED: From 162 identified records, five articles met all inclusion criteria; four studies included infected controls with no post-COVID symptoms whereas all five studies included non-infected controls (410 COVID-19 survivors with post-COVID symptoms, 223 COVID-19 survivors with no post-COVID symptoms as controls and 266 non-infected healthy controls). Four studies concluded that the presence of autoantibodies had a potential (but small) role in post-COVID-19 condition whereas one study concluded that autoantibodies were not associated. Quality assessment showed all studies had high methodological quality.
UNASSIGNED: Although evidence suggests that persistent autoantibodies can be associated with post-COVID symptoms, the clinical relevance of their presence seems modest at this stage. Current results highlight further research to clarify the role of autoantibodies in the development of post-COVID symptoms, guiding the development of tailored diagnostic and treatment approaches to enhance patient outcomes.
UNASSIGNED: https://osf.io/vqz28.
UNASSIGNED: PubMed/MEDLINE, CINAHL, EMBASE, and Web of Science databases, as well as on medRxiv and bioRxiv preprint servers were searched up to January 5th, 2024. Papers investigating the presence of autoantibodies in plasma/serum samples in people with post-COVID symptoms were included. The Newcastle-Ottawa Scale (NOS) was used to assess methodological quality.
UNASSIGNED: From 162 identified records, five articles met all inclusion criteria; four studies included infected controls with no post-COVID symptoms whereas all five studies included non-infected controls (410 COVID-19 survivors with post-COVID symptoms, 223 COVID-19 survivors with no post-COVID symptoms as controls and 266 non-infected healthy controls). Four studies concluded that the presence of autoantibodies had a potential (but small) role in post-COVID-19 condition whereas one study concluded that autoantibodies were not associated. Quality assessment showed all studies had high methodological quality.
UNASSIGNED: Although evidence suggests that persistent autoantibodies can be associated with post-COVID symptoms, the clinical relevance of their presence seems modest at this stage. Current results highlight further research to clarify the role of autoantibodies in the development of post-COVID symptoms, guiding the development of tailored diagnostic and treatment approaches to enhance patient outcomes.
UNASSIGNED: https://osf.io/vqz28.
摘要：
■自身抗体的长期持续存在是解释在患有COVID-19后疾病的个体中看到的多系统表现的假设之一。当前的评论对患有COVID后症状的人血浆/血清中自身抗体的持久性提供了有限的见解。
■PubMed/MEDLINE,CINAHL,EMBASE,和WebofScience数据库,以及在medRxiv和bioRxiv预打印服务器上进行了搜索，直到1月5日，2024.包括研究患有COVID后症状的人的血浆/血清样品中自身抗体存在的论文。纽卡斯尔-渥太华量表（NOS）用于评估方法学质量。
■从162条确定的记录中，五篇文章符合所有纳入标准；四项研究包括没有COVID后症状的感染对照，而所有五项研究包括未感染对照(410名有COVID-19后症状的COVID-19幸存者，223名没有COVID后症状的COVID-19幸存者作为对照，266名未感染的健康对照）。四项研究得出的结论是，自身抗体的存在在COVID-19后疾病中具有潜在的（但作用很小），而一项研究得出的结论是，自身抗体与之无关。质量评价显示所有研究均具有较高的方法学质量。
■尽管有证据表明持续性自身抗体可能与COVID后症状有关，在这个阶段，它们的存在的临床相关性似乎不大。目前的结果强调了进一步的研究，以阐明自身抗体在COVID后症状发展中的作用，指导开发量身定制的诊断和治疗方法，以提高患者的预后。
■https://osf.io/vqz28。
■PubMed/MEDLINE,CINAHL,EMBASE,和WebofScience数据库,以及在medRxiv和bioRxiv预打印服务器上进行了搜索，直到1月5日，2024.包括研究患有COVID后症状的人的血浆/血清样品中自身抗体存在的论文。纽卡斯尔-渥太华量表（NOS）用于评估方法学质量。
■从162条确定的记录中，五篇文章符合所有纳入标准；四项研究包括没有COVID后症状的感染对照，而所有五项研究包括未感染对照(410名有COVID-19后症状的COVID-19幸存者，223名没有COVID后症状的COVID-19幸存者作为对照，266名未感染的健康对照）。四项研究得出的结论是，自身抗体的存在在COVID-19后疾病中具有潜在的（但作用很小），而一项研究得出的结论是，自身抗体与之无关。质量评价显示所有研究均具有较高的方法学质量。
■尽管有证据表明持续性自身抗体可能与COVID后症状有关，在这个阶段，它们的存在的临床相关性似乎不大。目前的结果强调了进一步的研究，以阐明自身抗体在COVID后症状发展中的作用，指导开发量身定制的诊断和治疗方法，以提高患者的预后。
■https://osf.io/vqz28。
