Abstract：
Despite significant progress in understanding SARS-CoV-2 and its impact, a deeper comprehension of the molecular changes in the host following infection is still lacking. Proteomic analysis of COVID-19 infected patients can provide valuable data about the events and mechanisms related to the initial, progression, and terminal stages of the disease. Such information can lead to better prevention, treatment, and convalescence strategies. In this review, we discuss blood proteomic studies based on mass spectrometry in COVID-19 patients. The analysis focuses on various blood components including plasma, platelets, serum, red blood cells, and peripheral blood mononuclear cells. Scientific papers published since 2022 are covered, with approaches categorised based on whether they use in-gel, in-solution, or on-beads/on-filter digestion modes. Additionally, candidate protein biomarkers related to COVID-19 are surveyed and discussed.
摘要：
尽管在理解SARS-CoV-2及其影响方面取得了重大进展，对感染后宿主的分子变化仍缺乏更深入的理解。对COVID-19感染患者的蛋白质组学分析可以揭示与初始相关的事件和机制的有价值的数据，programming,和疾病的终末期。这些信息可以导致更好的预防，治疗,和疗养策略。在这次审查中,我们讨论了基于质谱的COVID-19患者血液蛋白质组学研究。分析的重点是各种血液成分，包括血浆，血小板,血清,红细胞,和外周血单核细胞。涵盖了自2022年以来发表的科学论文，方法根据是否使用凝胶进行分类，在解决方案中，或上珠/上过滤器消化模式。此外,对与COVID-19相关的候选蛋白质生物标志物进行了调查和讨论。
