增强的二硫键稳定性有助于 icodec 胰岛素的每周一次。
Mesh : Animals Humans Male Diabetes Mellitus, Type 2 / drug therapy metabolism blood Disulfides / chemistry Half-Life Hypoglycemic Agents / administration & dosage pharmacokinetics chemistry Insulin / administration & dosage metabolism chemistry pharmacokinetics Receptor, Insulin / metabolism Sulfhydryl Compounds / chemistry Swine Swine, Miniature
来 源:
DOI:10.1038/s41467-024-50477-9
PDF(Pubmed)