Abstract：
The utilization of ionic liquids (ILs) in pharmaceutical drug delivery applications has seen significant expansion in recent years, owing to their distinctive characteristics and inherent adjustability. These innovative compounds can be used to tackle challenges associated with traditional dosage forms, such as polymorphism, inadequate solubility, permeability, and efficacy in topical drug delivery systems. Here, we provide a brief classification of ILs, and their effectiveness in augmenting transmucosal drug delivery approaches by improving the solubility and permeability of active pharmaceutical ingredients (APIs) by temporary mucus modulation aiding the paracellular transport of APIs, prolonging drug retention, and, thus, aiding controlled drug release across various mucosal surfaces. We also highlight potential advances in, and future perspectives of, IL-based formulations in mucosal drug delivery.
摘要：
近年来,离子液体(ILs)在药物输送应用中的应用得到了显著的扩展。由于其独特的特点和固有的可调性。这些创新化合物可用于应对与传统剂型相关的挑战，如多态性，溶解度不足，渗透性,和局部药物递送系统的功效。这里,我们提供了IL的简要分类，以及它们通过临时粘液调节帮助API的细胞旁运输来改善活性药物成分（API）的溶解度和渗透性，从而增强经粘膜药物递送方法的有效性，延长药物滞留，and,因此，帮助药物在各种粘膜表面的受控释放。我们还强调了在以下方面的潜在进展，以及未来的前景，粘膜药物递送中的基于IL的制剂。
