Abstract：
Angiotensin II receptor blockers (ARBs) are contraindicated during pregnancy because of fetal toxicity. All previous reports on adverse fetal outcomes involved women who continued to take low-dose ARBs for hypertension and were unaware of the adverse effects. Herein, we report the case of a 23-year-old pregnant woman in her third trimester who experienced an ARB overdose after an argument with her partner. Pregnancy was complicated by transient oligohydramnios, and fetal magnetic resonance imaging suggested renal failure. Despite these concerns, the newborn had no morphological abnormalities or abnormal neurological findings. Renal impairment improved over time, and the infant grew well. A single overdose of ARBs in the third trimester can lead to fetal renal failure, similar to long-term low-dose ARB administration; however, favorable outcomes are possible. An overdose of ARBs may transiently cause renal failure, which may improve. The study findings may inform counseling for women who are unexpectedly exposed to an overdose of ARBs.
摘要：
由于胎儿毒性，血管紧张素II受体阻滞剂（ARB）在怀孕期间禁忌使用。以前所有关于不良胎儿结局的报告都涉及继续服用低剂量ARB治疗高血压的妇女，并且不知道其不良反应。在这里，我们报道了一例23岁妊娠晚期孕妇在与伴侣发生争执后出现ARB过量的病例.妊娠并发短暂性羊水过少，胎儿磁共振成像提示肾功能衰竭。尽管有这些担忧,新生儿无形态学异常或神经系统异常表现.肾功能损害随着时间的推移而改善，婴儿长得很好。妊娠晚期单次过量服用ARB可导致胎儿肾衰竭，类似于长期低剂量ARB给药；然而，有利的结果是可能的。过量服用ARB可能会短暂导致肾衰竭，这可能会有所改善。研究结果可能会为意外暴露于过量ARB的女性提供咨询。
