METHODS: In 2023, the Alzheimer\'s Association convened multidisciplinary researchers at the \"AAIC Advancements: APOE\" conference to discuss various topics, including apoE isoforms and their roles in AD pathogenesis, progress in apoE-targeted therapeutic strategies, updates on disease models and interventions that modulate apoE expression and function.
RESULTS: This manuscript presents highlights from the conference and provides an overview of opportunities for further research in the field.
CONCLUSIONS: Understanding apoE\'s multifaceted roles in AD pathogenesis will help develop targeted interventions for AD and advance the field of AD precision medicine.
CONCLUSIONS: APOE is a central player in the pathogenesis of Alzheimer\'s disease. APOE exerts a numerous effects throughout the brain on amyloid-beta, tau, and other pathways. The AAIC Advancements: APOE conference encouraged discussions and collaborations on understanding the role of APOE.
方法:2023年,阿尔茨海默氏症协会在“AAIC进步:APOE”会议上召集了多学科研究人员讨论各种主题,包括apoE亚型及其在AD发病机制中的作用,apoE靶向治疗策略的进展,关于调节apoE表达和功能的疾病模型和干预措施的更新。
结果:本手稿介绍了会议的亮点,并概述了该领域进一步研究的机会。
结论:了解apoE在AD发病机制中的多方面作用,将有助于制定针对AD的针对性干预措施,推进AD精准医学领域。
结论:APOE在阿尔茨海默病的发病机制中起着核心作用。APOE在整个大脑中对β淀粉样蛋白产生许多影响,tau,和其他途径。AAIC进步:APOE会议鼓励就理解APOE的作用进行讨论和合作。