Abstract：
BACKGROUND: The apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimer\'s disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid-beta and tau pathologies but also lipid and energy metabolism, neuroinflammation, cerebral vascular health, and sex-dependent disease manifestations. Furthermore, ancestral background may significantly impact the link between APOE and AD, underscoring the need for more inclusive research.
METHODS: In 2023, the Alzheimer\'s Association convened multidisciplinary researchers at the \"AAIC Advancements: APOE\" conference to discuss various topics, including apoE isoforms and their roles in AD pathogenesis, progress in apoE-targeted therapeutic strategies, updates on disease models and interventions that modulate apoE expression and function.
RESULTS: This manuscript presents highlights from the conference and provides an overview of opportunities for further research in the field.
CONCLUSIONS: Understanding apoE\'s multifaceted roles in AD pathogenesis will help develop targeted interventions for AD and advance the field of AD precision medicine.
CONCLUSIONS: APOE is a central player in the pathogenesis of Alzheimer\'s disease. APOE exerts a numerous effects throughout the brain on amyloid-beta, tau, and other pathways. The AAIC Advancements: APOE conference encouraged discussions and collaborations on understanding the role of APOE.
METHODS: In 2023, the Alzheimer\'s Association convened multidisciplinary researchers at the \"AAIC Advancements: APOE\" conference to discuss various topics, including apoE isoforms and their roles in AD pathogenesis, progress in apoE-targeted therapeutic strategies, updates on disease models and interventions that modulate apoE expression and function.
RESULTS: This manuscript presents highlights from the conference and provides an overview of opportunities for further research in the field.
CONCLUSIONS: Understanding apoE\'s multifaceted roles in AD pathogenesis will help develop targeted interventions for AD and advance the field of AD precision medicine.
CONCLUSIONS: APOE is a central player in the pathogenesis of Alzheimer\'s disease. APOE exerts a numerous effects throughout the brain on amyloid-beta, tau, and other pathways. The AAIC Advancements: APOE conference encouraged discussions and collaborations on understanding the role of APOE.
摘要：
背景：载脂蛋白E基因（APOE）是阿尔茨海默病（AD）发病机理中已确立的核心角色，具有不同的apoE亚型，发挥不同的作用。apoE不仅影响β淀粉样蛋白和tau病理，还影响脂质和能量代谢，神经炎症，脑血管健康，和性别依赖性疾病表现。此外，祖先背景可能会显著影响APOE和AD之间的联系，强调需要更具包容性的研究。
方法：2023年，阿尔茨海默氏症协会在“AAIC进步：APOE”会议上召集了多学科研究人员讨论各种主题，包括apoE亚型及其在AD发病机制中的作用，apoE靶向治疗策略的进展，关于调节apoE表达和功能的疾病模型和干预措施的更新。
结果：本手稿介绍了会议的亮点，并概述了该领域进一步研究的机会。
结论：了解apoE在AD发病机制中的多方面作用，将有助于制定针对AD的针对性干预措施，推进AD精准医学领域。
结论：APOE在阿尔茨海默病的发病机制中起着核心作用。APOE在整个大脑中对β淀粉样蛋白产生许多影响，tau,和其他途径。AAIC进步：APOE会议鼓励就理解APOE的作用进行讨论和合作。
方法：2023年，阿尔茨海默氏症协会在“AAIC进步：APOE”会议上召集了多学科研究人员讨论各种主题，包括apoE亚型及其在AD发病机制中的作用，apoE靶向治疗策略的进展，关于调节apoE表达和功能的疾病模型和干预措施的更新。
结果：本手稿介绍了会议的亮点，并概述了该领域进一步研究的机会。
结论：了解apoE在AD发病机制中的多方面作用，将有助于制定针对AD的针对性干预措施，推进AD精准医学领域。
结论：APOE在阿尔茨海默病的发病机制中起着核心作用。APOE在整个大脑中对β淀粉样蛋白产生许多影响，tau,和其他途径。AAIC进步：APOE会议鼓励就理解APOE的作用进行讨论和合作。
