%0 Journal Article
%T Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.
%A Kloske CM
%A Belloy ME
%A Blue EE
%A Bowman GR
%A Carrillo MC
%A Chen X
%A Chiba-Falek O
%A Davis AA
%A Paolo GD
%A Garretti F
%A Gate D
%A Golden LR
%A Heinecke JW
%A Herz J
%A Huang Y
%A Iadecola C
%A Johnson LA
%A Kanekiyo T
%A Karch CM
%A Khvorova A
%A Koppes-den Hertog SJ
%A Lamb BT
%A Lawler PE
%A Guen YL
%A Litvinchuk A
%A Liu CC
%A Mahinrad S
%A Marcora E
%A Marino C
%A Michaelson DM
%A Miller JJ
%A Morganti JM
%A Narayan PS
%A Naslavsky MS
%A Oosthoek M
%A Ramachandran KV
%A Ramakrishnan A
%A Raulin AC
%A Robert A
%A Saleh RNM
%A Sexton C
%A Shah N
%A Shue F
%A Sible IJ
%A Soranno A
%A Strickland MR
%A Tcw J
%A Thierry M
%A Tsai LH
%A Tuckey RA
%A Ulrich JD
%A van der Kant R
%A Wang N
%A Wellington CL
%A Weninger SC
%A Yassine HN
%A Zhao N
%A Bu G
%A Goate AM
%A Holtzman DM
%J Alzheimers Dement
%V 0
%N 0
%D 2024 Jul 19
%M 39031528
%F 16.655
%R 10.1002/alz.13877
%X <B>BACKGROUND: </B>The apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimer's disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid-beta and tau pathologies but also lipid and energy metabolism, neuroinflammation, cerebral vascular health, and sex-dependent disease manifestations. Furthermore, ancestral background may significantly impact the link between APOE and AD, underscoring the need for more inclusive research.<BR><B>METHODS: </B>In 2023, the Alzheimer's Association convened multidisciplinary researchers at the "AAIC Advancements: APOE" conference to discuss various topics, including apoE isoforms and their roles in AD pathogenesis, progress in apoE-targeted therapeutic strategies, updates on disease models and interventions that modulate apoE expression and function.<BR><B>RESULTS: </B>This manuscript presents highlights from the conference and provides an overview of opportunities for further research in the field.<BR><B>CONCLUSIONS: </B>Understanding apoE's multifaceted roles in AD pathogenesis will help develop targeted interventions for AD and advance the field of AD precision medicine.<BR><B>CONCLUSIONS: </B>APOE is a central player in the pathogenesis of Alzheimer's disease. APOE exerts a numerous effects throughout the brain on amyloid-beta, tau, and other pathways. The AAIC Advancements: APOE conference encouraged discussions and collaborations on understanding the role of APOE.