Abstract：
UNASSIGNED: Surgery may be associated with postoperative cognitive impairment in elder participants, yet the extent of its association with mild cognitive impairment (MCI) remains undetermined.
UNASSIGNED: To determine the relationship between surgery and MCI.
UNASSIGNED: The data of participants from the Alzheimer\'s Disease Neuroimaging Initiative were analyzed, including individuals with MCI or normal cognition. We focused on surgeries conducted after the age of 45, categorized by the number of surgeries, surgical risk, and the age at which surgeries occurred. Multivariable logistic regression was employed to determine the association between surgery and the development of MCI.
UNASSIGNED: The study is comprised of 387 individuals with MCI and 578 cognitively normal individuals. The overall surgery exposure (adjusted OR = 1.14, [95% CI 0.83, 1.56], p = 0.43) and the number of surgeries (adjusted OR = 0.92 [0.62, 1.36], p = 0.67 for single exposure, adjusted OR = 1.12 [0.71, 1.78], p = 0.63 for two exposures, adjusted OR = 1.38 [0.95, 2.01], p = 0.09 for three or more exposures compared to no exposure as the reference) were not associated with the development of MCI. However, high-risk surgeries (adjusted OR = 1.79 [1.00, 3.21], p = 0.049) or surgeries occurring after the age of 75 (adjusted OR = 2.01 [1.03, 3.90], p = 0.041) were associated with a greater risk of developing MCI.
UNASSIGNED: High risk surgeries occurring at an older age contribute to the development of MCI, indicating a complex of mechanistic insights for the development of postoperative cognitive impairment.
UNASSIGNED: To determine the relationship between surgery and MCI.
UNASSIGNED: The data of participants from the Alzheimer\'s Disease Neuroimaging Initiative were analyzed, including individuals with MCI or normal cognition. We focused on surgeries conducted after the age of 45, categorized by the number of surgeries, surgical risk, and the age at which surgeries occurred. Multivariable logistic regression was employed to determine the association between surgery and the development of MCI.
UNASSIGNED: The study is comprised of 387 individuals with MCI and 578 cognitively normal individuals. The overall surgery exposure (adjusted OR = 1.14, [95% CI 0.83, 1.56], p = 0.43) and the number of surgeries (adjusted OR = 0.92 [0.62, 1.36], p = 0.67 for single exposure, adjusted OR = 1.12 [0.71, 1.78], p = 0.63 for two exposures, adjusted OR = 1.38 [0.95, 2.01], p = 0.09 for three or more exposures compared to no exposure as the reference) were not associated with the development of MCI. However, high-risk surgeries (adjusted OR = 1.79 [1.00, 3.21], p = 0.049) or surgeries occurring after the age of 75 (adjusted OR = 2.01 [1.03, 3.90], p = 0.041) were associated with a greater risk of developing MCI.
UNASSIGNED: High risk surgeries occurring at an older age contribute to the development of MCI, indicating a complex of mechanistic insights for the development of postoperative cognitive impairment.
摘要：
■手术可能与老年参与者的术后认知障碍有关，然而,其与轻度认知障碍(MCI)的关联程度仍未确定.
■确定手术与MCI之间的关系。
■分析了来自阿尔茨海默病神经影像学计划的参与者的数据，包括具有MCI或正常认知的个体。我们专注于45岁以后进行的手术，按手术数量分类，手术风险,以及手术发生的年龄。采用多变量逻辑回归来确定手术与MCI发展之间的关系。
■该研究由387名MCI个体和578名认知正常个体组成。总体手术暴露（校正OR=1.14，[95%CI0.83，1.56]，p=0.43）和手术次数（调整后的OR=0.92[0.62，1.36]，对于单次曝光，p=0.67，调整后的OR=1.12[0.71，1.78]，对于两次曝光，p=0.63，调整后的OR=1.38[0.95，2.01]，与没有暴露作为参考相比，三次或更多次暴露的p=0.09）与MCI的发展无关。然而,高风险手术(调整后的OR=1.79[1.00，3.21]，p=0.049）或75岁以后进行的手术（调整后的OR=2.01[1.03，3.90]，p=0.041）与发生MCI的风险更大相关。
年龄较大的高风险手术有助于MCI的发展，表明对术后认知障碍发展的机制见解复杂。
■确定手术与MCI之间的关系。
■分析了来自阿尔茨海默病神经影像学计划的参与者的数据，包括具有MCI或正常认知的个体。我们专注于45岁以后进行的手术，按手术数量分类，手术风险,以及手术发生的年龄。采用多变量逻辑回归来确定手术与MCI发展之间的关系。
■该研究由387名MCI个体和578名认知正常个体组成。总体手术暴露（校正OR=1.14，[95%CI0.83，1.56]，p=0.43）和手术次数（调整后的OR=0.92[0.62，1.36]，对于单次曝光，p=0.67，调整后的OR=1.12[0.71，1.78]，对于两次曝光，p=0.63，调整后的OR=1.38[0.95，2.01]，与没有暴露作为参考相比，三次或更多次暴露的p=0.09）与MCI的发展无关。然而,高风险手术(调整后的OR=1.79[1.00，3.21]，p=0.049）或75岁以后进行的手术（调整后的OR=2.01[1.03，3.90]，p=0.041）与发生MCI的风险更大相关。
年龄较大的高风险手术有助于MCI的发展，表明对术后认知障碍发展的机制见解复杂。
