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Abstract：
Myeloid-derived growth factor (MYDGF) is a novel secreted protein with potent antiapoptotic and tissue-repairing properties that is present in nearly 140 human tissues and cell lines, with the highest abundance in the oral epithelium and skin. Initially, MYDGF was found in bone marrow-derived monocytes and macrophages for cardioprotection and repair after myocardial infarction. Subsequent studies have shown that MYDGF plays an important role in other cardiovascular diseases (e.g., atherosclerosis and heart failure), metabolic disorders, renal disease, autoimmune/inflammatory disorders, and cancers. Although the underlying mechanisms have not been fully explored, the role of MYDGF in health and disease may involve cell apoptosis and proliferation, tissue repair and regeneration, anti-inflammation, and glycolipid metabolism regulation. In this review, we summarize the current progress in understanding the role of MYDGF in health and disease, focusing on its structure, function and mechanisms. The graphical abstract shows the current role of MYDGF in different organs and diseases (Fig. 1).
摘要：
髓源性生长因子（MYDGF）是一种新型分泌蛋白，具有有效的抗凋亡和组织修复特性，存在于近140个人类组织和细胞系中。在口腔上皮和皮肤中丰度最高。最初，在骨髓来源的单核细胞和巨噬细胞中发现MYDGF用于心肌梗死后的心脏保护和修复。随后的研究表明，MYDGF在其他心血管疾病中起着重要作用（例如，动脉粥样硬化和心力衰竭)，代谢紊乱，肾脏疾病,自身免疫性/炎症性疾病，和癌症。尽管基本机制尚未得到充分探索，MYDGF在健康和疾病中的作用可能涉及细胞凋亡和增殖,组织修复和再生，抗炎，和糖脂代谢调节。在这次审查中,我们总结了目前在了解MYDGF在健康和疾病中的作用方面的进展，专注于它的结构，功能和机制。图形摘要显示了MYDGF在不同器官和疾病中的当前作用（图。1).
