Abstract：
The absence of blood flow in cerebral ischemic conditions triggers a multitude of intricate pathophysiological mechanisms, including excitotoxicity, oxidative stress, neuroinflammation, disruption of the blood-brain barrier and white matter disarrangement. Despite numerous experimental studies conducted in preclinical settings, existing treatments for cerebral ischemia (CI), such as mechanical and pharmacological therapies, remain constrained and often entail significant side effects. Therefore, there is an imperative to explore innovative strategies for addressing CI outcomes. Cannabidiol (CBD), the most abundant non-psychotomimetic compound derived from Cannabis sativa, is a pleiotropic substance that interacts with diverse molecular targets and has the potential to influence various pathophysiological processes, thereby contributing to enhanced outcomes in CI. This chapter provides a comprehensive overview of the primary effects of CBD in in vitro and diverse animal models of CI and delves into some of its plausible mechanisms of neuroprotection.
摘要：
脑缺血条件下血流的缺乏引发了许多复杂的病理生理机制，包括兴奋性毒性，氧化应激，神经炎症，破坏血脑屏障和白质紊乱。尽管在临床前环境中进行了许多实验研究，现有的脑缺血（CI）治疗方法，如机械和药物治疗，仍然受到限制，并且经常带来显著的副作用。因此,探索解决CI结果的创新策略势在必行。大麻二酚（CBD），来自大麻的最丰富的非拟态化合物，是一种多效性物质，与不同的分子靶标相互作用，并有可能影响各种病理生理过程，从而有助于增强CI的结果。本章全面概述了CBD在体外和多种CI动物模型中的主要作用，并探讨了其神经保护的一些合理机制。
