PDF(Pubmed)
Abstract：
MicroRNAs (miRNAs) are small non‑coding RNAs that serve key roles in cell proliferation, migration, invasion and apoptosis by regulating gene expression. In malignant tumors, miRNA‑122 serves either as a tumor suppressor or oncogene, influencing tumor progression via downstream gene targeting. However, the precise role of miRNA‑122 in cancer remains unclear. miRNA‑122 is a potential biomarker and modulator of radiotherapy and chemotherapy. The present review aimed to summarize the roles of miRNA‑122 in cancer, its potential as a biomarker for diagnosis and prognosis and its implications in cancer therapy, including radiotherapy and chemotherapy, alongside strategies for systemic delivery.
摘要：
microRNAs（miRNAs）是小的非编码RNA，在细胞增殖中起关键作用，迁移,通过调节基因表达进行侵袭和凋亡。在恶性肿瘤中，miRNA-122作为肿瘤抑制因子或癌基因，通过下游基因靶向影响肿瘤进展。然而,miRNA-122在癌症中的确切作用尚不清楚。miRNA-122是放疗和化疗的潜在生物标志物和调节剂。本综述旨在总结miRNA‑122在癌症中的作用，它作为诊断和预后的生物标志物的潜力及其在癌症治疗中的意义，包括放疗和化疗,以及系统交付的策略。
