%0 Journal Article
%T Role of miRNA‑122 in cancer (Review).
%A Zhang J
%A Wu L
%A Ding R
%A Deng X
%A Chen Z
%J Int J Oncol
%V 65
%N 3
%D 2024 Sep
%M 39027994
%F 5.884
%R 10.3892/ijo.2024.5671
%X MicroRNAs (miRNAs) are small non‑coding RNAs that serve key roles in cell proliferation, migration, invasion and apoptosis by regulating gene expression. In malignant tumors, miRNA‑122 serves either as a tumor suppressor or oncogene, influencing tumor progression via downstream gene targeting. However, the precise role of miRNA‑122 in cancer remains unclear. miRNA‑122 is a potential biomarker and modulator of radiotherapy and chemotherapy. The present review aimed to summarize the roles of miRNA‑122 in cancer, its potential as a biomarker for diagnosis and prognosis and its implications in cancer therapy, including radiotherapy and chemotherapy, alongside strategies for systemic delivery.