PDF(Pubmed)
Abstract：
Immunotherapy shows substantial advancement in cancer and is becoming widely used in clinical practice. A variety of biomarkers have been proposed to predict the efficacy of immunotherapy, but most of them have low predictive ability. Tertiary lymphoid structures (TLSs), the aggregation of multiple lymphocytes, have been found to exist in various tumor tissues. TLSs have been shown to correlate with patient prognosis and immunotherapy response. This review summarizes the characteristics of TLSs and the inducing factors of TLS formation, presents available evidence on the role of TLSs in predicting immunotherapy response in different cancers, and lastly emphasizes their predictive potential for neoadjuvant immunotherapy efficacy.
摘要：
免疫治疗在癌症中显示出实质性的进步，并在临床实践中得到广泛应用。已经提出了多种生物标志物来预测免疫疗法的疗效。但大多数预测能力较低。三级淋巴样结构（TLSs），多个淋巴细胞的聚集，已发现存在于各种肿瘤组织中。已显示TLS与患者预后和免疫治疗反应相关。本文综述了TLSs的特点和TLS形成的诱导因素,提供了有关TLS在预测不同癌症的免疫治疗反应中的作用的现有证据，最后强调了它们对新辅助免疫疗法疗效的预测潜力。
