关键词: Antioxidant capacity Cannabis oil Galenic formulations Long-term stability Total polyphenol content

Mesh : Cannabis / chemistry Anti-Bacterial Agents / pharmacology chemistry Plant Oils / pharmacology chemistry Animals Antioxidants / pharmacology chemistry Escherichia coli / drug effects Staphylococcus aureus / drug effects Drug Stability Sesame Oil / chemistry pharmacology Cannabinoids / pharmacology chemistry Larva / drug effects Polyphenols / pharmacology chemistry Flavonoids / pharmacology chemistry

来  源:   DOI:10.1016/j.fitote.2024.106128

Abstract:
The long-term stability in real and accelerated time for galenic oils based on full-spectrum cannabis has been studied, using sesame oil as a dilutant. Sesame oil is one of the most used vehicles in the cannabis pharmaceutical industry due to the costs and increased oral bioavailability of cannabinoids. The real-time assays conducted at 25 °C over twelve months demonstrated high stability and showed no significant changes in the composition of cannabinoids, total polyphenols, flavonoids, or antioxidant capacity. In these studies, it was observed that there was no development of microorganisms compromising the stability of the oils over a year. The three oil varieties exhibited a high bactericidal capacity against E. coli, S. aureus, and P. larvae.
摘要:
已经研究了基于全谱大麻的盖伦油在实际和加速时间中的长期稳定性,使用芝麻油作为稀释剂。由于大麻素的成本和增加的口服生物利用度,芝麻油是大麻制药业中最常用的载体之一。在25°C超过12个月进行的实时测定显示出高稳定性,并且大麻素的组成没有显着变化,总多酚,黄酮类化合物,或抗氧化能力。在这些研究中,据观察,在一年内没有微生物的发展损害油的稳定性。这三个油品种对大肠杆菌表现出很高的杀菌能力,金黄色葡萄球菌,还有P.幼虫.
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