Abstract：
BACKGROUND: Micronized purified flavonoid fraction (MPFF) is the most widely prescribed and well-studied venoactive drug available for the treatment of chronic venous disease (CVD). Photoplethysmography (PPG) is used to quantitatively measure venous hemodynamics and provide information about the overall function of the venous system. The aim of this study was to use digital PPG to evaluate the effects of MPFF on venous hemodynamics in patients with CVD.
METHODS: Patients diagnosed with CVD at an outpatient clinic in Bursa, Turkey between February 2018 and July 2020 were assessed for inclusion in this retrospective analysis. Patients who complied with the advised treatment strategy (MPFF 1,000 mg tablets taken orally once daily and compression garments) and attended follow-up visits were included in the analysis. Digital PPG was used to measure venous refilling time (VRT) and venous pumping capacity (VPC) at diagnosis and 6 months of follow-up. The Venous Clinical Severity Score (VCSS) was also obtained at these visits, and patients completed the 20-item Chronic Venous Insufficiency Questionnaire (CIVIQ-20).
RESULTS: In total, 721 patients (mean age 52 years) with C0-C4 CVD were included in the study. PPG showed that VRT and VPC increased significantly from 19.0 sec to 2.0%, respectively, at diagnosis to 27.4 and 4.9%, respectively, at 6 months (both P < 0.05). Mean VCSS improved significantly from 7.9 at diagnosis to 3.1 at 6 months (P < 0.05). Mean CIVIQ-20 score also improved significantly at the 6-month follow-up (20.1 vs 38.6 at diagnosis; P < 0.01).
CONCLUSIONS: In patients with C0-C4 CVD, 6 months of MPFF treatment plus the wearing of compression garments was associated with statistically significant improvements in venous hemodynamic parameters measured by PPG, as well as measures of clinical severity and quality of life.
METHODS: Patients diagnosed with CVD at an outpatient clinic in Bursa, Turkey between February 2018 and July 2020 were assessed for inclusion in this retrospective analysis. Patients who complied with the advised treatment strategy (MPFF 1,000 mg tablets taken orally once daily and compression garments) and attended follow-up visits were included in the analysis. Digital PPG was used to measure venous refilling time (VRT) and venous pumping capacity (VPC) at diagnosis and 6 months of follow-up. The Venous Clinical Severity Score (VCSS) was also obtained at these visits, and patients completed the 20-item Chronic Venous Insufficiency Questionnaire (CIVIQ-20).
RESULTS: In total, 721 patients (mean age 52 years) with C0-C4 CVD were included in the study. PPG showed that VRT and VPC increased significantly from 19.0 sec to 2.0%, respectively, at diagnosis to 27.4 and 4.9%, respectively, at 6 months (both P < 0.05). Mean VCSS improved significantly from 7.9 at diagnosis to 3.1 at 6 months (P < 0.05). Mean CIVIQ-20 score also improved significantly at the 6-month follow-up (20.1 vs 38.6 at diagnosis; P < 0.01).
CONCLUSIONS: In patients with C0-C4 CVD, 6 months of MPFF treatment plus the wearing of compression garments was associated with statistically significant improvements in venous hemodynamic parameters measured by PPG, as well as measures of clinical severity and quality of life.
摘要：
目的：微粉化的纯化黄酮类成分（MPFF）是治疗慢性静脉疾病（CVD）最广泛的处方和研究最充分的静脉活性药物。光电容积描记术（PPG）用于定量测量静脉血液动力学，并提供有关静脉系统整体功能的信息。这项研究的目的是使用数字PPG评估MPFF对CVD患者静脉血流动力学的影响。
方法：在布尔萨门诊诊断为CVD的患者，土耳其在2018年2月至2020年7月期间被评估纳入本回顾性分析。符合建议的治疗策略（每天口服一次MPFF1000mg片剂和压缩服）并参加随访的患者被纳入分析。在诊断和随访6个月时，使用数字PPG测量静脉再充盈时间（VRT）和静脉泵容量（VPC）。在这些访视时还获得了静脉临床严重程度评分（VCSS），患者完成20项慢性静脉功能不全生活质量问卷（CIVIQ-20）。
结果：总计，721例C0-C4CVD患者（平均年龄52岁）纳入研究。PPG显示，VRT和VPC从19.0秒和2.0%显著增加，分别,诊断为27.4%和4.9%，分别,在6个月时（均p<0.05）。平均VCSS从诊断时的7.9显著改善至6个月时的3.1(p<0.05)。MeanCIVIQ-20评分在6个月随访时也有显著改善(诊断时20.1vs38.6;p<0.01)。
结论：C0-C4CVD患者，6个月的MPFF治疗加上穿着压缩服装与通过PPG测量的静脉血流动力学参数的统计学显着改善相关。以及临床严重程度和生活质量的衡量标准。
方法：在布尔萨门诊诊断为CVD的患者，土耳其在2018年2月至2020年7月期间被评估纳入本回顾性分析。符合建议的治疗策略（每天口服一次MPFF1000mg片剂和压缩服）并参加随访的患者被纳入分析。在诊断和随访6个月时，使用数字PPG测量静脉再充盈时间（VRT）和静脉泵容量（VPC）。在这些访视时还获得了静脉临床严重程度评分（VCSS），患者完成20项慢性静脉功能不全生活质量问卷（CIVIQ-20）。
结果：总计，721例C0-C4CVD患者（平均年龄52岁）纳入研究。PPG显示，VRT和VPC从19.0秒和2.0%显著增加，分别,诊断为27.4%和4.9%，分别,在6个月时（均p<0.05）。平均VCSS从诊断时的7.9显著改善至6个月时的3.1(p<0.05)。MeanCIVIQ-20评分在6个月随访时也有显著改善(诊断时20.1vs38.6;p<0.01)。
结论：C0-C4CVD患者，6个月的MPFF治疗加上穿着压缩服装与通过PPG测量的静脉血流动力学参数的统计学显着改善相关。以及临床严重程度和生活质量的衡量标准。
