Mesh : Sleep / genetics physiology Circadian Rhythm / genetics physiology Humans Animals Gene Expression Regulation / genetics Circadian Clocks / genetics Biological Clocks / genetics

来  源:   DOI:10.1016/j.cels.2024.06.006

Abstract:
Rhythmic gene expression can originate not only from the autonomous rhythm of clock genes but likely also from sleep-wake cycles. Jan and colleagues used a novel model-based approach to dissect these individual effects and found that both factors contribute to gene expression rhythms, varying in degree within and across tissues.
摘要:
节律性基因表达不仅可以源自时钟基因的自主节律,还可能源自睡眠-觉醒周期。Jan和他的同事使用一种新的基于模型的方法来剖析这些个体效应,发现这两个因素都有助于基因表达节律,组织内和组织间的程度不同。
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