Migraine is a common headache disorder that presents with photophobia in many patients during attacks. Furthermore, some patients with migraine experience constant photophobia, even during headache-free intervals, leading to a compromised quality of life.
This prospective, case-control study included 40 patients with migraine (18 male and 22 female) who were recruited at an eye hospital and eye clinic. The patients were divided into two groups: migraine with photophobia group, consisting of 22 patients (10 male and 12 female) with constant photophobia, and migraine without photophobia group, consisting of 18 patients (eight male and 10 female) without constant photophobia. We used 18F-fluorodeoxyglucose and positron emission tomography to compare cerebral glucose metabolism between the two patient groups and 42 healthy participants (16 men and 26 women).
Compared with the healthy group, both the migraine with photophobia and migraine without photophobia groups showed cerebral glucose hypermetabolism in the bilateral thalamus (p < 0.05, family-wise error-corrected). Moreover, the contrast of migraine with photophobia minus migraine without photophobia patients showed glucose hypermetabolism in the bilateral medial thalamus (p < 0.05, family-wise error-corrected).
The medial thalamus may be associated with the development of continuous photophobia in patients with migraine.
背景:偏头痛是一种常见的头痛障碍,在许多患者发作期间表现为畏光。此外,一些偏头痛患者持续畏光,即使在无头痛的时间间隔,导致生活质量受损。
方法:这种前瞻性,病例对照研究纳入了40例偏头痛患者(男性18例,女性22例),他们在一家眼科医院和眼科诊所招募.将患者分为两组:偏头痛伴畏光组,由22名患者(10名男性和12名女性)组成,无畏光的偏头痛组,由18名患者(8名男性和10名女性)组成,没有持续畏光。我们使用18F-氟脱氧葡萄糖和正电子发射断层扫描来比较两个患者组和42名健康参与者(16名男性和26名女性)之间的脑葡萄糖代谢。
结果:与健康组相比,有畏光的偏头痛和无畏光的偏头痛组均显示双侧丘脑中的脑葡萄糖高代谢(p<0.05,经家族性误差校正)。此外,偏头痛伴畏光减去偏头痛不伴畏光患者的对比显示双侧内侧丘脑葡萄糖高代谢(p<0.05,经家族错误校正).
结论:内侧丘脑可能与偏头痛患者持续畏光的发展有关。