PDF(Pubmed)
Abstract：
Polycystic Ovary Syndrome (PCOS) is a multifaceted endocrine disorder that implicates a spectrum of clinical manifestations, including hormonal imbalance, metabolic dysfunction, and even compromised ovarian granulosa cell (GC) activity. The underlying molecular mechanisms of PCOS remain elusive, presenting a significant barrier to effective diagnosis and treatment. This review delves into the emerging role of long non-coding RNAs (lncRNAs) in the pathophysiology of PCOS, articulating their intricate interactions with mRNAs, microRNAs, and other epigenetic regulators that collectively influence the hormonal and metabolic milieu of PCOS. We examine the dynamic regulatory networks orchestrated by lncRNAs that impact GC function, steroidogenesis, insulin resistance, and inflammatory pathways. By integrating findings from recent studies, we illuminate the potential of lncRNAs as biomarkers for PCOS and highlight their contribution to the disorder, offering a detailed perspective on the lncRNA-mediated modulation of gene expression and pathogenic pathways. Understanding targeted lncRNA interactions with PCOS proposes novel avenues for therapeutic intervention to ameliorate the reproductive and metabolic disturbances characteristic of the syndrome.
摘要：
多囊卵巢综合征（PCOS）是一种涉及一系列临床表现的多方面内分泌疾病，包括荷尔蒙失调,代谢功能障碍，甚至损害卵巢颗粒细胞（GC）的活性。PCOS的潜在分子机制仍然难以捉摸，对有效诊断和治疗构成重大障碍。这篇综述探讨了长链非编码RNA（lncRNA）在PCOS病理生理学中的新作用。阐明它们与mRNA的复杂相互作用，microRNAs,和其他表观遗传调节因子共同影响PCOS的激素和代谢环境。我们研究了由影响GC功能的lncRNAs编排的动态调控网络，类固醇生成，胰岛素抵抗，和炎症途径。通过整合最近研究的发现，我们阐明了lncRNAs作为PCOS生物标志物的潜力，并强调了它们对该疾病的贡献，提供了关于lncRNA介导的基因表达和致病途径调节的详细观点。了解靶向lncRNA与PCOS的相互作用为治疗干预提供了新的途径，以改善该综合征的生殖和代谢紊乱特征。
