PDF(Pubmed)
Abstract：
An increase in ambient temperature leads to an increase in sleep. However, the mechanisms behind this phenomenon remain unknown. This study aimed to investigate the role of microglia in the increase of sleep caused by high ambient temperature. We confirmed that at 35 °C, slow-wave sleep was significantly increased relative to those observed at 25 °C. Notably, this effect was abolished upon treatment with PLX3397, a CSF1R inhibitor that can deplete microglia, while sleep amount at 25 °C was unaffected. These observations suggest that microglia play a pivotal role in modulating the homeostatic regulation of sleep in response to the fluctuations in ambient temperature.
摘要：
环境温度的升高导致睡眠增加。然而,这种现象背后的机制仍然未知。本研究旨在探讨小胶质细胞在高环境温度引起的睡眠增加中的作用。我们确认在35°C时,慢波睡眠相对于在25°C观察到的睡眠显着增加。值得注意的是,这种效应在PLX3397治疗后被消除，PLX3397是一种可以耗尽小胶质细胞的CSF1R抑制剂，而25°C时的睡眠量不受影响。这些观察结果表明，小胶质细胞在调节环境温度波动对睡眠的稳态调节中起着关键作用。
