PDF(Pubmed)
Abstract：
Relapsing polychondritis (RP) is a systemic immune mediated disease characterized by recurrent episodes of inflammation in various cartilage-rich areas. RP may cause extensive tissue destruction and is associated with significant morbidity and mortality. In this multicenter study, we considered the remission status and long-term outcomes of RP in patients who were followed-up in six referral rheumatology centers in Iran. Outcomes of disease was assessed by remission status and RP induced damage. A total of 29 patients with RP were examined for enrollment in the study, and 26 patients with a minimum follow-up period of 6 months were included in the RP outcome analysis. Median time to control of symptoms and sustained remission were 5 and 23 weeks, respectively. Prednisolone was discontinued in 8 (30.8%) patients and medication-free remission was achieved in 7 (23.1%) patients. Regarding the disease course, 34.6% of patients had a relapsing-remitting course, 42.3% had a monophasic course, and 23.1% had an always-active course. Despite extensive treatment with immunosuppressive medications, RP induced damage was developed in 21 (80.8%) patients. Ear deformity and osteoporosis were the most common RP induced damage. Long-term remission and medications-free remission in RP is accessible. However, RP related damage occur in majority of patients.
摘要：
复发性多软骨炎（RP）是一种全身性免疫介导的疾病，其特征是在各种富含软骨的区域反复发作的炎症。RP可引起广泛的组织破坏,并与显著的发病率和死亡率相关。在这项多中心研究中，我们考虑了在伊朗6个转诊风湿病中心随访的RP患者的缓解状态和长期结局.通过缓解状态和RP诱导的损害来评估疾病的结果。共有29名RP患者被纳入研究，将26例最少随访6个月的患者纳入RP结局分析.症状控制和持续缓解的中位时间分别为5周和23周，分别。8例（30.8％）患者停用泼尼松龙，7例（23.1％）患者无药物缓解。关于疾病的过程，34.6％的患者有复发缓解过程，42.3%有单相课程，23.1%的人总是活跃的。尽管使用免疫抑制药物进行了广泛的治疗，21例（80.8%）患者发生RP诱导的损伤。耳朵畸形和骨质疏松是RP引起的最常见损害。RP可获得长期缓解和无药物缓解。然而,RP相关损害发生在大多数患者中。
