PDF(Pubmed)
Abstract：
Suxamethonium is considered by many to be the best drug for providing ideal intubating conditions, short surgical procedures, and rapid sequence induction. However, its usefulness is limited by the frequent occurrence of adverse effects like postoperative myalgia. Therefore this study aimed to assess the prevalence and associated factors of postoperative suxamethonium-induced myalgia. An institutional-based cross-sectional study was conducted on 210 patients who underwent surgery with general anesthesia. The data was collected by using structured and pretested questionnaires and analyzed using SPSS version 20.0. Logistic regression was conducted to identify significant predictors based on a P-value of less than 0.05 with a 95% confidence level. Among 210 patients the prevalence of suxamethonium-induced postoperative myalgia in the first 48 h was 88 (41.9%). Patients having previous anesthesia and surgical exposure (AOR 5.29, 95% CI 1.86-15.05), patients having a co-existing disease (AOR 2.69, 95% CI 1.08-6.67), patients that had not taken premedication (analgesia) (AOR 4.64, 95% CI 1.69-12.74), anesthesia maintenance using halothane (AOR 4.5 95% CI 1.7-11.4) and relaxation maintained with suxamethonium (AOR 3.1, 95% CI 1.2-8.1) were significantly associated with the prevalence of postoperative myalgia. The magnitude of suxamethonium-induced postoperative myalgia was high. So it is better to do with preventive techniques. As much as possible it is better to avoid using suxamethonium and necessary to use better to Premedicate with nonsteroidal anti-inflammatory drugs and non-depolarizing neuromuscular medications.
摘要：
Suxamethonion被许多人认为是提供理想插管条件的最佳药物，短外科手术,和快速序列诱导。然而,其有用性受到诸如术后肌痛等不良反应频繁发生的限制。因此，本研究旨在评估术后甲胺铵引起的肌痛的患病率和相关因素。对210例接受全身麻醉手术的患者进行了基于机构的横断面研究。使用结构化和预测试问卷收集数据，并使用SPSS20.0版进行分析。进行逻辑回归以基于小于0.05的P值和95%的置信水平来识别显著的预测因子。在210例患者中，在前48小时内甲胺铵引起的术后肌痛的患病率为88（41.9％）。既往有麻醉和手术暴露的患者（AOR5.29，95％CI1.86-15.05），患有共存疾病的患者(AOR2.69，95%CI1.08-6.67)，未服用术前用药（镇痛）的患者（AOR4.64，95%CI1.69-12.74），使用氟烷的麻醉维持(AOR4.595%CI1.7-11.4)和使用甲胺铵维持松弛(AOR3.1,95%CI1.2-8.1)与术后肌痛的患病率显著相关.甲胺铵引起的术后肌痛程度很高。因此，最好使用预防技术。尽可能避免使用suxamethonium和必要更好地使用premedicate与非甾体抗炎药和非去极化神经肌肉药物。
