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Abstract：
Cationic polymers have great potential for cancer therapy due to their unique interactions with cancer cells. However, their clinical application remains limited by their high toxicity. Here we show a cell membrane-targeting cationic polymer with antineoplastic activity (Pmt) and a second near-infrared (NIR-II) fluorescent biodegradable polymer with photosensitizer Bodipy units and reactive oxygen species (ROS) responsive thioketal bonds (PBodipy). Subsequently, these two polymers can self-assemble into antineoplastic nanoparticles (denoted mt-NPBodipy) which could further accumulate at the tumor and destroy cell membranes through electrostatic interactions, resulting in cell membrane destabilization. Meanwhile, the photosensitizer Bodipy produces ROS to induce damage to cell membranes, proteins, and DNAs to kill cancer cells concertedly, finally resulting in cell membrane lysis and cancer cell death. This work highlights the use of near-infrared light to spatially and temporarily control cationic polymers for photodynamic therapy, photo-immunotherapy, and NIR-II fluorescence for bio-imaging.
摘要：
阳离子聚合物由于其与癌细胞的独特相互作用而具有用于癌症治疗的巨大潜力。然而,它们的高毒性仍然限制了它们的临床应用。在这里，我们展示了一种具有抗肿瘤活性（Pmt）的细胞膜靶向阳离子聚合物和第二种近红外（NIR-II）荧光可生物降解聚合物，其具有光敏剂Bodpy单元和活性氧（ROS）响应性硫缩醛键（PBodipy）。随后，这两种聚合物可以自组装成抗肿瘤纳米颗粒（称为mt-NPBodipy），可以在肿瘤处进一步积累并通过静电相互作用破坏细胞膜，导致细胞膜不稳定。同时,光敏剂Bodipy产生ROS以诱导细胞膜损伤，蛋白质，和DNA协同杀死癌细胞，最终导致细胞膜裂解和癌细胞死亡。这项工作强调了使用近红外光在空间和暂时控制阳离子聚合物进行光动力疗法，光免疫疗法,和NIR-II荧光用于生物成像。
