Abstract：
Glioma is the most common intracranial malignant tumor, with severe difficulty in treatment and a low patient survival rate. Due to the heterogeneity and invasiveness of tumors, lack of personalized clinical treatment design, and physiological barriers, it is often difficult to accurately distinguish gliomas, which dramatically affects the subsequent diagnosis, imaging treatment, and prognosis. Fortunately, nano-delivery systems have demonstrated unprecedented capabilities in diagnosing and treating gliomas in recent years. They have been modified and surface modified to efficiently traverse BBB/BBTB, target lesion sites, and intelligently release therapeutic or contrast agents, thereby achieving precise imaging and treatment. In this review, we focus on nano-delivery systems. Firstly, we provide an overview of the standard and emerging diagnostic and treatment technologies for glioma in clinical practice. After induction and analysis, we focus on summarizing the delivery methods of drug delivery systems, the design of nanoparticles, and their new advances in glioma imaging and treatment in recent years. Finally, we discussed the prospects and potential challenges of drug-delivery systems in diagnosing and treating glioma.
摘要：
胶质瘤是颅内最常见的恶性肿瘤，治疗困难严重，患者生存率低。由于肿瘤的异质性和侵袭性，缺乏个性化的临床治疗设计，和生理障碍，通常很难准确区分胶质瘤，这极大地影响了随后的诊断，成像治疗,和预后。幸运的是,近年来，纳米递送系统在诊断和治疗神经胶质瘤方面表现出前所未有的能力。它们已被修饰和表面修饰，以有效地穿越BBB/BBTB，靶病变部位,并智能地释放治疗剂或造影剂，从而实现精确的成像和治疗。在这次审查中,我们专注于纳米递送系统。首先,我们概述了临床实践中神经胶质瘤的标准和新兴诊断和治疗技术。经过归纳和分析,重点总结了给药系统的给药方法,纳米粒子的设计，以及近年来他们在胶质瘤成像和治疗方面的新进展。最后,我们讨论了药物递送系统在诊断和治疗胶质瘤中的前景和潜在挑战。
