Abstract：
BACKGROUND: Gender-specific interventions are crucial in addressing substance use disorders -particularly cannabis use disorder - as they allow for tailored therapeutic approaches and increase the likelihood of successful outcomes. However, differences in therapeutic processes and outcomes between males and females are often not observed, making the prognosis and development of such interventions more difficult.
OBJECTIVE: This study aimed to examine the moderating role of sex in the relationship between treatment admission profile characterized by indicators of cannabis use and sociodemographic sources of gender inequality (e.g., employment status) and adherence and outcome at discharge.
METHODS: A multicentric retrospective observational study was conducted with a sample of 3,814 outpatients diagnosed with cannabis use disorder. Electronic health records were used for data analysis.
RESULTS: The interaction between sex and the number of children, as well as pre-treatment cannabis use, predicted lower treatment adherence, particularly among females. Additionally, the interaction between sex and the number of children predicted outcomes at discharge, with females showing a higher likelihood of dropout compared to males.
CONCLUSIONS: Enhanced comprehensive treatment with intensified contingency management programs should be prioritized for females (especially those with children) who have consumed cannabis in the month before treatment. Adopting a treatment policy framework incorporating sex/gender-sensitive therapist training and evaluative measures is essential for optimizing treatment outcomes for all patients.
OBJECTIVE: This study aimed to examine the moderating role of sex in the relationship between treatment admission profile characterized by indicators of cannabis use and sociodemographic sources of gender inequality (e.g., employment status) and adherence and outcome at discharge.
METHODS: A multicentric retrospective observational study was conducted with a sample of 3,814 outpatients diagnosed with cannabis use disorder. Electronic health records were used for data analysis.
RESULTS: The interaction between sex and the number of children, as well as pre-treatment cannabis use, predicted lower treatment adherence, particularly among females. Additionally, the interaction between sex and the number of children predicted outcomes at discharge, with females showing a higher likelihood of dropout compared to males.
CONCLUSIONS: Enhanced comprehensive treatment with intensified contingency management programs should be prioritized for females (especially those with children) who have consumed cannabis in the month before treatment. Adopting a treatment policy framework incorporating sex/gender-sensitive therapist training and evaluative measures is essential for optimizing treatment outcomes for all patients.
摘要：
背景：性别特异性干预措施对于解决物质使用障碍-特别是大麻使用障碍-至关重要，因为它们允许定制的治疗方法并增加成功结果的可能性。然而,男性和女性之间的治疗过程和结果的差异往往没有观察到，使得此类干预措施的预后和发展更加困难。
目的：这项研究旨在研究性别在以大麻使用指标为特征的治疗入院概况与性别不平等的社会人口统计学来源之间的关系中的调节作用（例如，就业状况)以及出院时的依从性和结果。
方法：对3,814名被诊断为大麻使用障碍的门诊患者进行了一项多中心回顾性观察性研究。使用电子健康记录进行数据分析。
结果：性别与儿童数量之间的相互作用，以及预处理大麻的使用，预测较低的治疗依从性，尤其是女性。此外,性别和儿童数量之间的相互作用预测出院时的结果，与男性相比，女性的辍学可能性更高。
结论：对于在治疗前一个月内吸食大麻的女性（尤其是有孩子的女性），应优先考虑加强应急管理方案的综合治疗。采用纳入性别/性别敏感的治疗师培训和评估措施的治疗政策框架对于优化所有患者的治疗结果至关重要。
目的：这项研究旨在研究性别在以大麻使用指标为特征的治疗入院概况与性别不平等的社会人口统计学来源之间的关系中的调节作用（例如，就业状况)以及出院时的依从性和结果。
方法：对3,814名被诊断为大麻使用障碍的门诊患者进行了一项多中心回顾性观察性研究。使用电子健康记录进行数据分析。
结果：性别与儿童数量之间的相互作用，以及预处理大麻的使用，预测较低的治疗依从性，尤其是女性。此外,性别和儿童数量之间的相互作用预测出院时的结果，与男性相比，女性的辍学可能性更高。
结论：对于在治疗前一个月内吸食大麻的女性（尤其是有孩子的女性），应优先考虑加强应急管理方案的综合治疗。采用纳入性别/性别敏感的治疗师培训和评估措施的治疗政策框架对于优化所有患者的治疗结果至关重要。
