Abstract：
During its temporary tenure, the placenta has extensive and specialized functions that are critical for pre- and post-natal development. The consequences of chemical exposure in utero can have profound effects on the structure and function of pregnancy-associated tissues and the life-long health of the birthing person and their offspring. However, the toxicological importance and critical functions of the placenta to embryonic and fetal development and maturation have been understudied. This narrative will review early placental development in humans and highlight some in vitro models currently in use that are or can be applied to better understand placental processes underlying developmental toxicity due to in utero environmental exposures.
摘要：
在其临时任期内，胎盘具有广泛和专门的功能，这对产前和产后发育至关重要。子宫内化学暴露的后果会对妊娠相关组织的结构和功能以及分娩者及其后代的终身健康产生深远的影响。然而,胎盘对胚胎和胎儿发育和成熟的毒理学重要性和关键功能尚未得到充分研究。本叙述将回顾人类早期胎盘发育，并强调目前使用的一些体外模型，这些模型可以或可以用于更好地了解由于子宫内环境暴露而导致的发育毒性的胎盘过程。
