Abstract：
The Human Exposome Project aims to revolutionize our understanding of how environmental exposures affect human health by systematically cataloging and analyzing the myriad exposures individuals encounter throughout their lives. This initiative draws a parallel with the Human Genome Project, expanding the focus from genetic factors to the dynamic and complex nature of environ-mental interactions. The project leverages advanced methodologies such as omics technologies, biomonitoring, microphysiological systems (MPS), and artificial intelligence (AI), forming the foun-dation of exposome intelligence (EI) to integrate and interpret vast datasets. Key objectives include identifying exposure-disease links, prioritizing hazardous chemicals, enhancing public health and regulatory policies, and reducing reliance on animal testing. The Implementation Moonshot Project for Alternative Chemical Testing (IMPACT), spearheaded by the Center for Alternatives to Animal Testing (CAAT), is a new element in this endeavor, driving the creation of a public-private part-nership toward a Human Exposome Project with a stakeholder forum in 2025. Establishing robust infrastructure, fostering interdisciplinary collaborations, and ensuring quality assurance through sys-tematic reviews and evidence-based frameworks are crucial for the project\'s success. The expected outcomes promise transformative advancements in precision public health, disease prevention, and a more ethical approach to toxicology. This paper outlines the strategic imperatives, challenges, and opportunities that lie ahead, calling on stakeholders to support and participate in this landmark initiative for a healthier, more sustainable future.
This paper outlines a proposal for a “Human Exposome Project” to comprehensively study how environmental exposures affect human health throughout our lives. The exposome refers to all the environmental factors we are exposed to, from chemicals to diet to stress. The project aims to use advanced technologies like artificial intelligence, lab-grown mini-organs, and detailed biological measurements to map how different exposures impact our health. This could help identify causes of diseases and guide better prevention strategies. Key goals include finding links between specific exposures and health problems, determining which chemicals are most concerning, improving public health policies, and reducing animal testing. The project requires collaboration between researchers, government agencies, companies, and others. While ambitious, this effort could revolutionize our understanding of environmental health risks. The potential benefits for improving health and preventing disease make this an important endeavor to a precise and comprehensive approach to public health and disease prevention.
This paper outlines a proposal for a “Human Exposome Project” to comprehensively study how environmental exposures affect human health throughout our lives. The exposome refers to all the environmental factors we are exposed to, from chemicals to diet to stress. The project aims to use advanced technologies like artificial intelligence, lab-grown mini-organs, and detailed biological measurements to map how different exposures impact our health. This could help identify causes of diseases and guide better prevention strategies. Key goals include finding links between specific exposures and health problems, determining which chemicals are most concerning, improving public health policies, and reducing animal testing. The project requires collaboration between researchers, government agencies, companies, and others. While ambitious, this effort could revolutionize our understanding of environmental health risks. The potential benefits for improving health and preventing disease make this an important endeavor to a precise and comprehensive approach to public health and disease prevention.
摘要：
人类暴露体项目旨在通过系统地编目和分析个人一生中遇到的无数暴露，彻底改变我们对环境暴露如何影响人类健康的理解。这项计划与人类基因组计划平行，将焦点从遗传因素扩展到环境相互作用的动态和复杂性质。该项目利用了先进的方法论，如组学技术，生物监测,微生理系统（MPS），和人工智能(AI)，形成暴露智能(EI)的基础，以整合和解释大量数据集。关键目标包括确定暴露与疾病的联系，优先考虑危险化学品，加强公共卫生和监管政策，减少对动物试验的依赖。替代化学品测试（IMPACT）实施月球项目，由动物试验替代方案中心（CAAT）牵头，是这项工作中的新元素，在2025年与利益相关者论坛一起推动建立公私合作关系，以实现人类外显子组项目。建立强大的基础设施，促进跨学科合作，通过系统审查和基于证据的框架确保质量保证对于项目的成功至关重要。预期的结果预示着精准公共卫生的变革性进步，疾病预防,和更道德的毒理学方法。本文概述了战略要务，挑战,和未来的机遇，呼吁利益相关者支持和参与这一具有里程碑意义的倡议，以实现更健康的目标，更可持续的未来
本文概述了一项“人类外显子组项目”的建议，以全面研究环境暴露如何影响我们一生的人类健康。暴露是指我们暴露于的所有环境因素，从化学物质到饮食再到压力。该项目旨在使用人工智能等先进技术，实验室培养的微型器官,和详细的生物测量，以绘制不同的暴露如何影响我们的健康。这可以帮助确定疾病的原因并指导更好的预防策略。关键目标包括发现特定暴露与健康问题之间的联系，确定哪些化学品最令人担忧，改善公共卫生政策，减少动物试验。该项目需要研究人员之间的合作，政府机构,公司,和其他人。虽然雄心勃勃，这一努力可以重新激发我们对环境健康风险的理解。改善健康和预防疾病的潜在好处使这成为对公共卫生和疾病预防采取精确和全面方法的重要努力。
本文概述了一项“人类外显子组项目”的建议，以全面研究环境暴露如何影响我们一生的人类健康。暴露是指我们暴露于的所有环境因素，从化学物质到饮食再到压力。该项目旨在使用人工智能等先进技术，实验室培养的微型器官,和详细的生物测量，以绘制不同的暴露如何影响我们的健康。这可以帮助确定疾病的原因并指导更好的预防策略。关键目标包括发现特定暴露与健康问题之间的联系，确定哪些化学品最令人担忧，改善公共卫生政策，减少动物试验。该项目需要研究人员之间的合作，政府机构,公司,和其他人。虽然雄心勃勃，这一努力可以重新激发我们对环境健康风险的理解。改善健康和预防疾病的潜在好处使这成为对公共卫生和疾病预防采取精确和全面方法的重要努力。
