PDF(Pubmed)
Abstract：
Aging represents a complex biological progression affecting the entire body, marked by a gradual decline in tissue function, rendering organs more susceptible to stress and diseases. The human heart holds significant importance in this context, as its aging process poses life-threatening risks. It entails macroscopic morphological shifts and biochemical changes that collectively contribute to diminished cardiac function. Among the numerous pivotal factors in aging, mitochondria play a critical role, intersecting with various molecular pathways and housing several aging-related agents. In this comprehensive review, we provide an updated overview of the functional role of mitochondria in cardiac aging.
摘要：
衰老代表了影响整个身体的复杂生物进程，以组织功能逐渐下降为标志，使器官更容易受到压力和疾病的影响。在这种情况下，人类的心脏具有重要的意义，因为它的老化过程会带来危及生命的风险。它需要宏观的形态变化和生化变化，共同导致心脏功能减弱。在衰老的众多关键因素中，线粒体起着关键作用，与各种分子途径相交，并容纳几种与衰老相关的药物。在这次全面审查中，我们提供了线粒体在心脏衰老中的功能作用的最新概述.
