{Reference Type}: Journal Article
{Title}: Dysfunctional mitochondria elicit bioenergetic decline in the aged heart.
{Author}: Mone P;Agyapong ED;Morciano G;Jankauskas SS;De Luca A;Varzideh F;Pinton P;Santulli G;
{Journal}: J Cardiovasc Aging
{Volume}: 4
{Issue}: 2
{Year}: 2024 Apr
暂无{DOI}: 10.20517/jca.2023.50
{Abstract}: Aging represents a complex biological progression affecting the entire body, marked by a gradual decline in tissue function, rendering organs more susceptible to stress and diseases. The human heart holds significant importance in this context, as its aging process poses life-threatening risks. It entails macroscopic morphological shifts and biochemical changes that collectively contribute to diminished cardiac function. Among the numerous pivotal factors in aging, mitochondria play a critical role, intersecting with various molecular pathways and housing several aging-related agents. In this comprehensive review, we provide an updated overview of the functional role of mitochondria in cardiac aging.