Abstract：
BACKGROUND: Autologous fat transfer (AFT) has been proposed as a possible treatment for scar tissue and its associated symptoms. Its effectiveness\'s evidence is yet unidentified though. The aim of this meta-analysis is to evaluate the currently available evidence on the efficacy and safety of autologous fat transfer in treating post-burn and post-traumatic scars using a validated scar measurement tool.
METHODS: This study performed a systematic literature review in November 2023 using the following electronic databases: MEDLINE, SCOPUS, Directory of Open Access Journals (DOAJ), PUBMED, and Google Scholar. The following key terms were included: (Fat grafting OR Autologous fat transfer) AND (body scars OR body burns OR body wounds) AND (Efficacy OR Safety OR satisfaction). We evaluated articles according to predefined quality criteria. The following data were included during the extraction period: patient demographics, indications for AFT, the number of AFT sessions, follow-up periods, and changes in the Patient and Observer Scar Assessment Scale (POSAS) scores, which contain both the patient and observer components.
RESULTS: This study included 1326 patients and 23 published articles. A total of 14 prospective studies, 7 retrospective studies, and 2 Randomized clinical trials studies were evaluated. These 23 articles came from diverse global locations; the earliest was published in 1992, and the most recently published in 2022.
CONCLUSIONS: Our findings demonstrated significant enhancements in scar characteristics from both patient and observer perspectives. Overall, AFT holds promise as a valuable treatment option for scar-related conditions as it enhances scar quality ,contributing to improved patient outcomes and satisfaction.
METHODS: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to Table of Contents or the online Instructions to Authors www.springer.com/00266.
METHODS: This study performed a systematic literature review in November 2023 using the following electronic databases: MEDLINE, SCOPUS, Directory of Open Access Journals (DOAJ), PUBMED, and Google Scholar. The following key terms were included: (Fat grafting OR Autologous fat transfer) AND (body scars OR body burns OR body wounds) AND (Efficacy OR Safety OR satisfaction). We evaluated articles according to predefined quality criteria. The following data were included during the extraction period: patient demographics, indications for AFT, the number of AFT sessions, follow-up periods, and changes in the Patient and Observer Scar Assessment Scale (POSAS) scores, which contain both the patient and observer components.
RESULTS: This study included 1326 patients and 23 published articles. A total of 14 prospective studies, 7 retrospective studies, and 2 Randomized clinical trials studies were evaluated. These 23 articles came from diverse global locations; the earliest was published in 1992, and the most recently published in 2022.
CONCLUSIONS: Our findings demonstrated significant enhancements in scar characteristics from both patient and observer perspectives. Overall, AFT holds promise as a valuable treatment option for scar-related conditions as it enhances scar quality ,contributing to improved patient outcomes and satisfaction.
METHODS: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to Table of Contents or the online Instructions to Authors www.springer.com/00266.
摘要：
背景：已提出自体脂肪转移（AFT）作为瘢痕组织及其相关症状的可能治疗方法。然而，其有效性的证据尚未确定。这项荟萃分析的目的是使用经过验证的疤痕测量工具评估现有的关于自体脂肪转移治疗烧伤后和创伤后疤痕的有效性和安全性的证据。
方法：本研究于2023年11月使用以下电子数据库进行了系统的文献综述：MEDLINE，Scopus,开放存取期刊目录(DOAJ)，pubmed,谷歌学者。包括以下关键术语:(脂肪移植或自体脂肪转移)和(身体疤痕或身体烧伤或身体创伤)和(功效或安全性或满意度)。我们根据预定的质量标准评估文章。提取期间包括以下数据：患者人口统计学，AFT指示,AFT会话的数量，后续期,以及患者和观察者疤痕评估量表（POSAS）评分的变化，其中包含患者和观察者的成分。
结果：本研究包括1326名患者和23篇发表的文章。共有14项前瞻性研究，7个回顾性研究，并对2项随机临床试验进行了评价。这23篇文章来自全球各地，最早发表于1992年，最近发表于2022年。
结论：我们的研究结果表明，从患者和观察者的角度来看，瘢痕特征都有显著增强。总的来说,AFT有望成为与疤痕相关的疾病的有价值的治疗选择，因为它可以提高疤痕质量。有助于改善患者的预后和满意度。
方法：本期刊要求作者为每篇文章分配一定程度的证据。对于这些循证医学评级的完整描述，请参阅目录或在线作者说明www。springer.com/00266.
方法：本研究于2023年11月使用以下电子数据库进行了系统的文献综述：MEDLINE，Scopus,开放存取期刊目录(DOAJ)，pubmed,谷歌学者。包括以下关键术语:(脂肪移植或自体脂肪转移)和(身体疤痕或身体烧伤或身体创伤)和(功效或安全性或满意度)。我们根据预定的质量标准评估文章。提取期间包括以下数据：患者人口统计学，AFT指示,AFT会话的数量，后续期,以及患者和观察者疤痕评估量表（POSAS）评分的变化，其中包含患者和观察者的成分。
结果：本研究包括1326名患者和23篇发表的文章。共有14项前瞻性研究，7个回顾性研究，并对2项随机临床试验进行了评价。这23篇文章来自全球各地，最早发表于1992年，最近发表于2022年。
结论：我们的研究结果表明，从患者和观察者的角度来看，瘢痕特征都有显著增强。总的来说,AFT有望成为与疤痕相关的疾病的有价值的治疗选择，因为它可以提高疤痕质量。有助于改善患者的预后和满意度。
方法：本期刊要求作者为每篇文章分配一定程度的证据。对于这些循证医学评级的完整描述，请参阅目录或在线作者说明www。springer.com/00266.
