PDF(Pubmed)
Abstract：
While the hippocampus is key for human cognitive abilities, it is also a phylogenetically old cortex and paradoxically considered evolutionarily preserved. Here, we introduce a comparative framework to quantify preservation and reconfiguration of hippocampal organisation in primate evolution, by analysing the hippocampus as an unfolded cortical surface that is geometrically matched across species. Our findings revealed an overall conservation of hippocampal macro- and micro-structure, which shows anterior-posterior and, perpendicularly, subfield-related organisational axes in both humans and macaques. However, while functional organisation in both species followed an anterior-posterior axis, we observed a marked reconfiguration in the latter across species, which mirrors a rudimentary integration of the default-mode-network in non-human primates. Here we show that microstructurally preserved regions like the hippocampus may still undergo functional reconfiguration in primate evolution, due to their embedding within heteromodal association networks.
摘要：
海马体是人类认知能力的关键,它也是一个系统发育古老的皮质，自相矛盾地认为是进化保存的。这里,我们引入了一个比较框架来量化灵长类动物进化中海马组织的保存和重新配置，通过将海马体分析为在物种之间几何匹配的展开的皮质表面。我们的发现揭示了海马宏观和微观结构的整体保守性，它显示了前-后和，垂直,人类和猕猴中与子场相关的组织轴。然而,虽然两个物种的功能组织都遵循前后轴，我们观察到后者在物种之间有明显的重新配置，这反映了默认模式网络在非人类灵长类动物中的基本整合。在这里，我们表明，像海马这样的微观结构保存区域在灵长类动物进化中可能仍然经历功能重构，由于它们嵌入在异型关联网络中。
