%0 Journal Article
%T Hippocampal connectivity patterns echo macroscale cortical evolution in the primate brain.
%A Eichert N
%A DeKraker J
%A Howard AFD
%A Huszar IN
%A Zhu S
%A Sallet J
%A Miller KL
%A Mars RB
%A Jbabdi S
%A Bernhardt BC
%J Nat Commun
%V 15
%N 1
%D 2024 Jul 16
%M 39013855
%F 17.694
%R 10.1038/s41467-024-49823-8
%X While the hippocampus is key for human cognitive abilities, it is also a phylogenetically old cortex and paradoxically considered evolutionarily preserved. Here, we introduce a comparative framework to quantify preservation and reconfiguration of hippocampal organisation in primate evolution, by analysing the hippocampus as an unfolded cortical surface that is geometrically matched across species. Our findings revealed an overall conservation of hippocampal macro- and micro-structure, which shows anterior-posterior and, perpendicularly, subfield-related organisational axes in both humans and macaques. However, while functional organisation in both species followed an anterior-posterior axis, we observed a marked reconfiguration in the latter across species, which mirrors a rudimentary integration of the default-mode-network in non-human primates. Here we show that microstructurally preserved regions like the hippocampus may still undergo functional reconfiguration in primate evolution, due to their embedding within heteromodal association networks.