Abstract：
BACKGROUND: Fatigue is reportedly associated with a poor prognosis in dialysis patients. The aim of the present study was to investigate whether fatigue on dialysis days or non-dialysis days is associated with mortality in patients on chronic hemodialysis.
METHODS: This was a prospective study of 134 hemodialysis patients. The level of fatigue was evaluated using a visual analog scale (VAS). The association between high fatigue evaluated by the highest quartile of the VAS value and all-cause death was investigated.
RESULTS: The fatigue scale score was significantly higher on dialysis than on non-dialysis days. During the follow-up period (median 6.8 years), 42 patients died. Patients with high post-dialysis fatigue in the higher quartiles died more frequently compared to those with in the lower quartiles (p = 0.012). Multivariate Cox regression analysis showed that high post-dialysis fatigue was an independent predictor of all-cause death (adjusted hazard ratio 2.12, 95% confidence interval 1.10-4.07).
CONCLUSIONS: Higher post-dialysis fatigue is related to increased mortality.
METHODS: This was a prospective study of 134 hemodialysis patients. The level of fatigue was evaluated using a visual analog scale (VAS). The association between high fatigue evaluated by the highest quartile of the VAS value and all-cause death was investigated.
RESULTS: The fatigue scale score was significantly higher on dialysis than on non-dialysis days. During the follow-up period (median 6.8 years), 42 patients died. Patients with high post-dialysis fatigue in the higher quartiles died more frequently compared to those with in the lower quartiles (p = 0.012). Multivariate Cox regression analysis showed that high post-dialysis fatigue was an independent predictor of all-cause death (adjusted hazard ratio 2.12, 95% confidence interval 1.10-4.07).
CONCLUSIONS: Higher post-dialysis fatigue is related to increased mortality.
摘要：
背景：据报道，疲劳与透析患者的不良预后相关。本研究的目的是调查透析日或非透析日的疲劳是否与慢性血液透析患者的死亡率相关。
方法：这是一项针对134名血液透析患者的前瞻性研究。使用视觉模拟量表（VAS）评估疲劳水平。研究了通过VAS值的最高四分位数评估的高度疲劳与全因死亡之间的关联。
结果：透析天数的疲劳量表评分明显高于非透析天数。在随访期间（中位数为6.8年），42名患者死亡。与较低四分位数的患者相比，较高四分位数的透析后疲劳患者死亡频率更高（p=0.012）。多因素Cox回归分析显示透析后高疲劳度是全因死亡的独立预测因子(调整后风险比2.12,95%置信区间1.10-4.07)。
结论：较高的透析后疲劳与死亡率增加有关。
方法：这是一项针对134名血液透析患者的前瞻性研究。使用视觉模拟量表（VAS）评估疲劳水平。研究了通过VAS值的最高四分位数评估的高度疲劳与全因死亡之间的关联。
结果：透析天数的疲劳量表评分明显高于非透析天数。在随访期间（中位数为6.8年），42名患者死亡。与较低四分位数的患者相比，较高四分位数的透析后疲劳患者死亡频率更高（p=0.012）。多因素Cox回归分析显示透析后高疲劳度是全因死亡的独立预测因子(调整后风险比2.12,95%置信区间1.10-4.07)。
结论：较高的透析后疲劳与死亡率增加有关。
