Abstract：
Ferroptosis is a novel iron-dependent form of cell death discovered in recent years, characterized by the accumulation of ferrous iron, the production of reactive oxygen species (ROS) through the Fenton reaction, and lipid peroxidation, ultimately leading to the disruption of the antioxidant system and cell membrane damage. Extensive research has found that ferroptosis plays a significant role in regulating tumor cell immune evasion, tumor development, and remodeling the tumor microenvironment. Small Extracellular vesicles (sEVs), carrying various bioactive molecules (ncRNA, DNA, proteins), are key nanoscale mediators of intercellular communication. Increasing evidence confirms that EVs can regulate the ferroptosis pathway in tumors, promoting tumor cell immune evasion and reshaping the tumor microenvironment. This article aims to comprehensively review the key mechanisms by which sEVs mediate ferroptosis in cancer and provide new insights into targeting tumor immunotherapy.
摘要：
铁凋亡是近年来发现的一种新的铁依赖性细胞死亡形式，以亚铁积累为特征，通过Fenton反应产生活性氧（ROS），和脂质过氧化，最终导致抗氧化系统的破坏和细胞膜的损伤。广泛的研究发现，铁凋亡在调节肿瘤细胞免疫逃避中起着重要作用，肿瘤发展，重塑肿瘤微环境。小细胞外囊泡（sEV），携带各种生物活性分子(ncRNA，DNA,蛋白质），是细胞间通讯的关键纳米尺度介质。越来越多的证据证实，电动汽车可以调节肿瘤中的铁凋亡途径，促进肿瘤细胞免疫逃避，重塑肿瘤微环境。本文旨在全面综述sEV介导肿瘤铁凋亡的关键机制，为靶向肿瘤免疫治疗提供新的见解。
