UNASSIGNED: In this single-center retrospective study, we reviewed consecutive breast cancer patients who developed brain metastasis and were treated with hypofractionated radiation therapy plus WBRT using intensity-modulated radiation therapy (IMRT)-SIB approaches. We analyzed clinical outcomes, prognostic factors and patterns of treatment failure.
UNASSIGNED: A total of 27 patients were eligible for analysis. Four (14.8%) patients achieved clinical complete response and 14 (51.9%) had partial response of brain lesions. The other nine patients were not evaluated for brain tumor response. The median brain progression-free survival was 8.60 (95% CI [6.43-13.33]) months and the median overall survival was 16.8 (95% CI [13.3-27.7]) months. Three patients had in-field failure, five had out-field failure and two had in-field and out-field failure.
UNASSIGNED: WBRT plus SIB led to improved tumor control and clinical outcome in breast cancer patients with brain metastasis.
■在这项单中心回顾性研究中,我们回顾了连续的乳腺癌患者,这些患者发生了脑转移,并接受了使用调强放疗(IMRT)-SIB方法的大分割放疗加WBRT治疗.我们分析了临床结果,治疗失败的预后因素和模式。
■共有27名患者符合分析条件。4例(14.8%)患者获得了临床完全缓解,14例(51.9%)的脑部病变部分缓解。其他9名患者未评估脑肿瘤反应。中位脑无进展生存期为8.60(95%CI[6.43-13.33])个月,中位总生存期为16.8(95%CI[13.3-27.7])个月。三名患者在现场失败,五个有场外故障,两个有场内和场外故障。
■WBRT加SIB改善了乳腺癌脑转移患者的肿瘤控制和临床预后。