PDF(Pubmed)
Abstract：
Postmenopausal osteoporosis (PMOP) is a major health problem affecting millions of women worldwide. PMOP patients are often accompanied by abnormal accumulation of bone marrow adipose tissue (BMAT). BMAT is a critical regulator of bone homeostasis, and an increasing BMAT volume is negatively associated with bone mass reduction or fracture. BMAT regulates bone metabolism via adipokines, cytokines and the immune system, but the specific mechanisms are largely unknown. This review emphasizes the impact of estrogen deficiency on bone homeostasis and BMAT expansion, and the mechanism by which BMAT regulates PMOP, providing a promising strategy for targeting BMAT in preventing and treating PMOP.
摘要：
绝经后骨质疏松症（PMOP）是影响全球数百万妇女的主要健康问题。PMOP患者常伴有骨髓脂肪组织(BMAT)的异常积聚。BMAT是骨骼稳态的关键调节剂，BMAT体积的增加与骨量减少或骨折呈负相关。BMAT通过脂肪因子调节骨代谢，细胞因子和免疫系统，但具体机制在很大程度上是未知的。这篇综述强调了雌激素缺乏对骨稳态和BMAT扩张的影响。以及BMAT调节PMOP的机制，为靶向BMAT预防和治疗PMOP提供了有希望的策略。
