Abstract：
Crosstalk between T cells and airway smooth muscle (ASM) may play a role in modulating asthmatic airway inflammation and remodelling. Infiltrating T cells have been observed within the ASM bundles of asthmatics, and a wide range of direct and indirect interactions between T cells and ASM have been demonstrated using various in vitro and in vivo model systems. Contact-dependent mechanisms such as ligation and activation of cellular adhesion and costimulatory molecules, as well as the formation of lymphocyte-derived membrane conduits, facilitate the adhesion, bidirectional communication and transfer of materials between T and ASM cells. T cell-derived cytokines, particularly of the Th1, Th2 and Th17 subsets, modulate the secretome, proliferation and contractility of ASM cells. This review summarizes the mechanisms governing T cell-ASM crosstalk in the context of asthma. Understanding the underlying mechanistic basis is important for directing future research and developing therapeutic interventions targeted towards this complex interaction.
摘要：
T细胞与气道平滑肌（ASM）之间的串扰可能在调节哮喘气道炎症和重塑中起作用。已经在哮喘患者的ASM束中观察到浸润的T细胞，使用各种体外和体内模型系统已经证明了T细胞和ASM之间的各种直接和间接相互作用。接触依赖性机制，如细胞粘附和共刺激分子的连接和激活，以及淋巴细胞衍生的膜导管的形成，促进粘合，T细胞和ASM细胞之间物质的双向通信和转移。T细胞衍生的细胞因子，特别是Th1，Th2和Th17子集，调节分泌体，ASM细胞的增殖和收缩性。本文综述了哮喘中T细胞-ASM串扰的机制。了解潜在的机制基础对于指导未来的研究和开发针对这种复杂相互作用的治疗干预措施非常重要。
