{Reference Type}: Journal Article
{Title}: T cell and airway smooth muscle interaction: a key driver of asthmatic airway inflammation and remodelling.
{Author}: Zhou M;Sun R;Jang J;Martin JG;
{Journal}: Am J Physiol Lung Cell Mol Physiol
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jul 16
{Factor}: 6.011
{DOI}: 10.1152/ajplung.00121.2024
{Abstract}: Crosstalk between T cells and airway smooth muscle (ASM) may play a role in modulating asthmatic airway inflammation and remodelling. Infiltrating T cells have been observed within the ASM bundles of asthmatics, and a wide range of direct and indirect interactions between T cells and ASM have been demonstrated using various in vitro and in vivo model systems. Contact-dependent mechanisms such as ligation and activation of cellular adhesion and costimulatory molecules, as well as the formation of lymphocyte-derived membrane conduits, facilitate the adhesion, bidirectional communication and transfer of materials between T and ASM cells. T cell-derived cytokines, particularly of the Th1, Th2 and Th17 subsets, modulate the secretome, proliferation and contractility of ASM cells. This review summarizes the mechanisms governing T cell-ASM crosstalk in the context of asthma. Understanding the underlying mechanistic basis is important for directing future research and developing therapeutic interventions targeted towards this complex interaction.